PMID- 10852471
OWN - NLM
STAT- MEDLINE
DCOM- 20000623
LR  - 20221207
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 85
IP  - 6
DP  - 2000 Jun
TI  - 3beta-hydroxysteroid dehydrogenase autoantibodies are rare in premature ovarian 
      failure.
PG  - 2324-6
AB  - Premature ovarian failure (POF) is a disorder of heterogeneous etiology, and 
      autoimmunity has been suspected as one cause of POF. The steroidogenic enzyme, 
      3beta-hydroxysteroid dehydrogenase (3betaHSD), has been characterized as a 
      potential autoantigen in POF as well as in insulin-dependent diabetes mellitus 
      (type 1 diabetes). Here we studied the presence of steroid cell antibodies (SCA), 
      autoantibodies to 3betaHSD and to two other known autoantigens in ovarian 
      failure, steroidogenic enzymes 17alpha-hydroxylase (P450c17), and side-chain 
      cleavage enzyme (P450scc) in POF patients and patient groups with autoimmune 
      polyendocrinopathy syndromes type 1 and 2 (APS1 and -2), isolated Addison's 
      disease, type 1 diabetes, and healthy controls. The SCA were found in 2 of 48 
      POF, 11 of 15 APS1, and 1 of 9 APS2, and autoantibodies to in vitro translated 
      3betaHSD protein were detected in 1 POF serum associated with Addison's disease 
      and 3 APS1 sera. All 3betaHSD precipitating sera were also positive for SCA. 
      However, no SCA or 3betaHSD autoantibodies were found in 38 Addison's disease, 28 
      type 1 diabetes, and 71 healthy control sera. In analysis of autoantibodies to 
      P450c17 and P450scc, antibodies to these enzymes were not found in POF sera, but 
      were found in 10 and 12 APS1 patient sera, respectively, and 1 APS2 patient serum 
      contained anti-P450c17 antibodies. Our results show that autoantibodies to 
      3betaHSD in POF patients are rare and are also found in patients with APS1.
FAU - Reimand, K
AU  - Reimand K
AD  - Institute of General and Molecular Pathology, University of Tartu, Estonia. 
      reimand@ut.ee
FAU - Peterson, P
AU  - Peterson P
FAU - Hyoty, H
AU  - Hyoty H
FAU - Uibo, R
AU  - Uibo R
FAU - Cooke, I
AU  - Cooke I
FAU - Weetman, A P
AU  - Weetman AP
FAU - Krohn, K J
AU  - Krohn KJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - EC 1.1.- (3-Hydroxysteroid Dehydrogenases)
SB  - IM
MH  - 3-Hydroxysteroid Dehydrogenases/*immunology
MH  - Addison Disease/enzymology/immunology
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Autoantibodies/*blood
MH  - Autoantigens/immunology
MH  - England
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Primary Ovarian Insufficiency/*enzymology/*immunology
MH  - Reference Values
MH  - Thyroiditis, Autoimmune/enzymology/immunology
MH  - Turner Syndrome/enzymology/immunology
MH  - White People
EDAT- 2000/06/14 09:00
MHDA- 2000/07/06 11:00
CRDT- 2000/06/14 09:00
PHST- 2000/06/14 09:00 [pubmed]
PHST- 2000/07/06 11:00 [medline]
PHST- 2000/06/14 09:00 [entrez]
AID - 10.1210/jcem.85.6.6630 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2000 Jun;85(6):2324-6. doi: 10.1210/jcem.85.6.6630.