PMID- 10852530
OWN - NLM
STAT- MEDLINE
DCOM- 20000713
LR  - 20220316
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 110
IP  - 6
DP  - 2000 Jun
TI  - Nasal interleukin-5, immunoglobulin E, eosinophilic cationic protein, and soluble 
      intercellular adhesion molecule-1 in chronic sinusitis, allergic rhinitis, and 
      nasal polyposis.
PG  - 1056-62
AB  - OBJECTIVE: To compare concentrations of interleukin-5 (IL-5), immunoglobulin E 
      (IgE), eosinophilic cationic protein (ECP), and soluble intercellular adhesion 
      molecule-1 (sICAM-1) in nasal secretion and serum of patients with chronic 
      nonallergic sinusitis, allergic rhinitis, and nonallergic nasal polyposis to 
      obtain information about the pathogenesis of these diseases. METHODS: Nasal 
      secretion and serum were analyzed by routine enzyme-linked immunosorbent assay 
      techniques. Nineteen patients with chronic nonallergic sinusitis, 24 patients 
      with seasonal allergic rhinitis, and 18 patients with nonallergic nasal polyposis 
      were included in the study. Eight healthy, nonallergic probands served as control 
      subjects. RESULTS: Significantly elevated concentrations of IL-5 (5-fold, P < 
      .05) and IgE (15-fold, P < .01) were detected in nasal secretion of patients with 
      allergic rhinitis (IL-5, 51.8 +/- 13.2 pg/mL; IgE, 41.9 +/- 20.9 kU/L) or 
      nonallergic nasal polyposis (IL-5, 57.9 +/- 36.9 pg(mL; IgE, 40.5 +/- 20.2 kU/L) 
      compared with controls (IL-5, 10.6 +/- 7.8 pg/mL; IgE, 2.8 +/- 0.5 kU/L) or with 
      patients with chronic nonallergic sinusitis (IL-5, 16.5 +/- 13.2 pg/mL; IgE, 5.4 
      +/- 3.1 kU/L). There were no significant differences between patients with 
      allergic rhinitis and those with nonallergic nasal polyposis. Concentrations of 
      ECP were significantly elevated (sixfold, P < .01) in patients with allergic 
      rhinitis (297.8 ng/mL +/- 173.1) compared with controls (52.4 +/- 28.0 ng/mL) or 
      patients with chronic nonallergic sinusitis (44.8 +/- 40.1 ng/mL), whereas 
      twofold higher concentrations (not significant) of ECP were observed in patients 
      with nonallergic nasal polyposis (107.1 +/- 26.6 ng/mL). Significantly elevated 
      concentrations of sICAM-1 in nasal secretion (threefold, P < .05) were detected 
      only in patients with chronic nonallergic sinusitis (79.4 +/- 45.6 ng/mL). The 
      elevated sICAM-1 nasal secretion values in this group correlated significantly (P 
      < .05) to the serum values. CONCLUSIONS: Equally elevated concentrations of IL-5 
      and IgE in patients with allergic rhinitis and nonallergic nasal polyposis 
      implicated similar pathogenic processes in both diseases. Whereas the 
      pathogenesis of allergic rhinitis is IgE-specific, the pathogenesis of nasal 
      polyps is not as clear. IL-5 was suggested to play a pivotal role in tissue 
      eosinophilia, which was confirmed by data in the present study. Elevated 
      concentrations of ECP were suggested to result from tissue eosinophilia--a 
      characteristic of both diseases. Elevated concentrations of sICAM-1 in patients 
      with chronic nonallergic sinusitis pointed to its key role in the recruitment of 
      neutrophils into the inflamed tissue, whereas an important role in eosinophil 
      recruitment was ruled out.
FAU - Kramer, M F
AU  - Kramer MF
AD  - Department of Otorhinolaryngology--Head and Neck Surgery, Ludwig Maximilians 
      University, Munich, Germany.
FAU - Ostertag, P
AU  - Ostertag P
FAU - Pfrogner, E
AU  - Pfrogner E
FAU - Rasp, G
AU  - Rasp G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 0 (Blood Proteins)
RN  - 0 (Eosinophil Granule Proteins)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-5)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Proteins/metabolism
MH  - Chronic Disease
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Eosinophil Granule Proteins
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Inflammation Mediators/*metabolism
MH  - Intercellular Adhesion Molecule-1/immunology
MH  - Interleukin-5/metabolism
MH  - Male
MH  - Middle Aged
MH  - Mucus/immunology
MH  - Nasal Mucosa/metabolism
MH  - Nasal Polyps/*immunology
MH  - Rhinitis, Allergic, Seasonal/*immunology
MH  - *Ribonucleases
MH  - Sinusitis/*immunology
EDAT- 2000/06/14 09:00
MHDA- 2000/07/15 11:00
CRDT- 2000/06/14 09:00
PHST- 2000/06/14 09:00 [pubmed]
PHST- 2000/07/15 11:00 [medline]
PHST- 2000/06/14 09:00 [entrez]
AID - 00005537-200006000-00031 [pii]
AID - 10.1097/00005537-200006000-00031 [doi]
PST - ppublish
SO  - Laryngoscope. 2000 Jun;110(6):1056-62. doi: 10.1097/00005537-200006000-00031.