PMID- 10852745
OWN - NLM
STAT- MEDLINE
DCOM- 20000801
LR  - 20220316
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 161
IP  - 6
DP  - 2000 Jun
TI  - Increased levels of circulating interleukin-18 in patients with advanced 
      tuberculosis.
PG  - 1786-9
AB  - Interleukin-18 (IL-18) has recently been identified as an interferon- 
      gamma-inducing factor and it plays an important role in the Th1 response. We 
      measured serum levels of IL-18 and interferon-gamma (IFN-gamma) in 43 patients 
      with pulmonary tuberculosis and 25 healthy control subjects. Significantly 
      increased levels of circulating IL-18 and IFN-gamma were found in pulmonary 
      tuberculosis as compared with those in healthy control subjects. Circulating 
      IL-18 and IFN-gamma correlated with the extent of disease in pulmonary 
      tuberculosis. We found significantly increased levels of circulating IL-18 and 
      IFN-gamma in the patients with high-grade fever. Circulating IL-18 significantly 
      correlated with circulating IFN-gamma. IL-18 may play an important role in immune 
      response to human infection with Mycobacterium tuberculosis.
FAU - Yamada, G
AU  - Yamada G
AD  - Third Department of Internal Medicine, Sapporo Medical University School of 
      Medicine, Sapporo, Japan.
FAU - Shijubo, N
AU  - Shijubo N
FAU - Shigehara, K
AU  - Shigehara K
FAU - Okamura, H
AU  - Okamura H
FAU - Kurimoto, M
AU  - Kurimoto M
FAU - Abe, S
AU  - Abe S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Interleukin-18)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
CIN - Am J Respir Crit Care Med. 2000 Jun;161(6):1773-4. PMID: 10852738
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Interferon-gamma/*blood
MH  - Interleukin-18/*blood
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium tuberculosis/immunology
MH  - Reference Values
MH  - Tuberculosis, Pulmonary/diagnosis/*immunology
EDAT- 2000/06/14 09:00
MHDA- 2000/08/06 11:00
CRDT- 2000/06/14 09:00
PHST- 2000/06/14 09:00 [pubmed]
PHST- 2000/08/06 11:00 [medline]
PHST- 2000/06/14 09:00 [entrez]
AID - 10.1164/ajrccm.161.6.9911054 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2000 Jun;161(6):1786-9. doi: 
      10.1164/ajrccm.161.6.9911054.