PMID- 10853858
OWN - NLM
STAT- MEDLINE
DCOM- 20001018
LR  - 20190822
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 15
IP  - 5
DP  - 2000 May
TI  - Distribution of DRB1 and DQB1 HLA class II alleles in occupational asthma due to 
      western red cedar.
PG  - 911-4
AB  - Occupational asthma caused by western red cedar is a common problem in sawmill 
      industries. The objective of this study was to examine a possible association of 
      human leukocyte antigen (HLA) class II genetic markers with susceptibility or 
      resistance to western red cedar induced asthma. The distribution of DRB1 and DQB1 
      HLA class II alleles and DRB1-DQB1 haplotypes was studied in 56 Caucasian 
      patients with proven red cedar asthma and 63 healthy Caucasian control subjects 
      exposed to red cedar dust. DRB1 and DQB1 high resolution typing was performed by 
      the polymerase chain reaction-based method. Patients with red cedar asthma had a 
      higher frequency of HLA DQB1*0603 and DQB1*0302 alleles compared to a group of 
      healthy exposed control subjects and a reduced frequency of DQB1*0501 allele. The 
      frequency of the DRB1*0401-DQB1* 0302 haplotype was increased and the 
      DRB1*0101-DQB1*0501 haplotype was reduced. These findings suggest that genetic 
      factors such as human leukocyte antigen class II antigens may be associated with 
      susceptibility or resistance to development of red cedar asthma.
FAU - Horne, C
AU  - Horne C
AD  - Immunology Laboratory, Vancouver Hospital and Health Sciences Centre, BC, Canada.
FAU - Quintana, P J
AU  - Quintana PJ
FAU - Keown, P A
AU  - Keown PA
FAU - Dimich-Ward, H
AU  - Dimich-Ward H
FAU - Chan-Yeung, M
AU  - Chan-Yeung M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04:01 antigen)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Asthma/*genetics
MH  - DNA/analysis
MH  - Disease Susceptibility
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Occupational Diseases/*genetics
MH  - *Wood
EDAT- 2000/06/15 09:00
MHDA- 2000/10/21 11:01
CRDT- 2000/06/15 09:00
PHST- 2000/06/15 09:00 [pubmed]
PHST- 2000/10/21 11:01 [medline]
PHST- 2000/06/15 09:00 [entrez]
AID - 10.1034/j.1399-3003.2000.15e17.x [doi]
PST - ppublish
SO  - Eur Respir J. 2000 May;15(5):911-4. doi: 10.1034/j.1399-3003.2000.15e17.x.