PMID- 10854034
OWN - NLM
STAT- MEDLINE
DCOM- 20001017
LR  - 20181113
IS  - 0895-8696 (Print)
IS  - 0895-8696 (Linking)
VI  - 14
IP  - 1-2
DP  - 2000 Feb-Apr
TI  - Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after 
      administration of antipsychotic and psychotrophic agents.
PG  - 27-37
AB  - We have investigated the potential role of neurotrophic factors in antipsychotic 
      drug action by examining the effects of antipsychotic and psychotropic treatments 
      on the mRNA expression of brain-derived neurotrophic factor (BDNF), 
      neurotrophin-3 (NT-3), and their receptors, trkB and trkC, respectively, in rat 
      brain. Neither acute nor chronic clozapine treatment significantly affected the 
      expression of these mRNAs in any brain area investigated, except for a decrease 
      in trkB expression in the granule cells of the olfactory bulb. We then examined 
      the effects of the psychotropic agent MK-801. MK-801 (5 mg/kg; 4 h) significantly 
      increased BDNF mRNA in the entorhinal cortex, but did not influence NT-3, trkB, 
      or trkC expression in any brain area except for the olfactory bulb. The induction 
      of BDNF mRNA by MK-801 was attenuated by pre-treatment (1 h prior to MK-801 
      administration) with the antipsychotics, clozapine (25 mg/kg) and haloperidol (2 
      mg/kg), but not with the antidepressant desipramine (15 mg/kg). Finally, we 
      confirmed that the effects of MK-801 on BDNF mRNA were reflected in the 
      respective changes in BDNF protein levels: MK-801 significantly increased 
      anti-BDNF reactivity in the entorhinal cortex (126 +/- 7% of control) while 
      concomitantly decreasing in the hippocampus (71 +/- 2% of control). These data do 
      not support the hypothesis that neurotrophins play an important role in 
      antipsychotic drug action, but rather suggest that induction of BDNF in the 
      entorhinal cortex may play a significant role in the psychotropic action of 
      MK-801.
FAU - Linden, A M
AU  - Linden AM
AD  - A. I. Virtanen Institute, University of Kuopio, Finland.
FAU - Vaisanen, J
AU  - Vaisanen J
FAU - Lakso, M
AU  - Lakso M
FAU - Nawa, H
AU  - Nawa H
FAU - Wong, G
AU  - Wong G
FAU - Castren, E
AU  - Castren E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Psychotropic Drugs)
RN  - 0 (RNA, Messenger)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
RN  - J60AR2IKIC (Clozapine)
SB  - IM
MH  - Animals
MH  - Antipsychotic Agents/*pharmacology
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Clozapine/*pharmacology
MH  - Dizocilpine Maleate/pharmacology
MH  - Entorhinal Cortex/metabolism
MH  - Gene Expression Regulation/*drug effects
MH  - Hippocampus/metabolism
MH  - Male
MH  - Neurotrophin 3/*genetics
MH  - Psychotropic Drugs/*pharmacology
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/*genetics
MH  - Receptor, trkC/*genetics
MH  - Transcription, Genetic/drug effects
EDAT- 2000/06/15 09:00
MHDA- 2000/10/21 11:01
CRDT- 2000/06/15 09:00
PHST- 1999/09/14 00:00 [received]
PHST- 1999/10/05 00:00 [accepted]
PHST- 2000/06/15 09:00 [pubmed]
PHST- 2000/10/21 11:01 [medline]
PHST- 2000/06/15 09:00 [entrez]
AID - JMN:14:1-2:027 [pii]
AID - 10.1385/JMN:14:1-2:027 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2000 Feb-Apr;14(1-2):27-37. doi: 10.1385/JMN:14:1-2:027.