PMID- 10854651 OWN - NLM STAT- MEDLINE DCOM- 20000727 LR - 20221115 IS - 0165-5728 (Print) IS - 0165-5728 (Linking) VI - 107 IP - 2 DP - 2000 Jul 24 TI - The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis. PG - 161-6 AB - Autoreactive T cells are a component of the normal immune system. It has been proposed that some of these autoreactive T cells even have a protective function. Recent studies support this notion by demonstrating that (a) myelin basic-protein (MBP-) specific T cells show neuroprotective effects in vivo, and (b) activated antigen-specific human T cells and other immune cells produce bioactive brain-derived neurotrophic factor (BDNF) in vitro. Furthermore, BDNF is expressed in different types of inflammatory cells in brain lesions of patients with acute disseminated leukoencephalopathy or multiple sclerosis. We postulate that the neuroprotective effect of T cells and other immune cells observed in vivo is at least partially mediated by BDNF and other neurotrophic factors. The concept of neuroprotective autoimmunity has obvious implications for the therapy of multiple sclerosis and other neuroimmunological diseases. FAU - Hohlfeld, R AU - Hohlfeld R AD - Institute for Clinical Neuroimmunology and Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, Marchioninistrasse 15, D-81366, Munich, Germany. hohlfeld@neuro.mpg.de FAU - Kerschensteiner, M AU - Kerschensteiner M FAU - Stadelmann, C AU - Stadelmann C FAU - Lassmann, H AU - Lassmann H FAU - Wekerle, H AU - Wekerle H LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - Netherlands TA - J Neuroimmunol JT - Journal of neuroimmunology JID - 8109498 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Neuroprotective Agents) SB - IM MH - Brain-Derived Neurotrophic Factor/immunology/*therapeutic use MH - Humans MH - Multiple Sclerosis/*drug therapy/*immunology MH - Neuroprotective Agents/immunology/*therapeutic use MH - T-Lymphocytes/immunology RF - 42 EDAT- 2000/06/16 00:00 MHDA- 2000/06/16 00:01 CRDT- 2000/06/16 00:00 PHST- 2000/06/16 00:00 [pubmed] PHST- 2000/06/16 00:01 [medline] PHST- 2000/06/16 00:00 [entrez] AID - S0165572800002332 [pii] AID - 10.1016/s0165-5728(00)00233-2 [doi] PST - ppublish SO - J Neuroimmunol. 2000 Jul 24;107(2):161-6. doi: 10.1016/s0165-5728(00)00233-2.