PMID- 10854797 OWN - NLM STAT- MEDLINE DCOM- 20000803 LR - 20211203 IS - 0378-3782 (Print) IS - 0378-3782 (Linking) VI - 58 IP - 2 DP - 2000 May TI - Underexpression of neural cell adhesion molecule and neurotrophic factors in rat brain following thromboxane A(2)-induced intrauterine growth retardation. PG - 101-10 AB - Intrauterine growth retardation (IUGR) often results in clinical neurodevelopmental disorders. To clarify the influence of uteroplacental insufficiency on central nervous system development, we have created a model of IUGR in rats using maternal administration of synthetic thromboxane A(2). We investigated expression patterns of neural cell adhesion molecule (NCAM) and reelin in this model by semiquantitative competitive polymerase chain reactions. On postnatal day 2, NCAM expression was decreased in rat cerebral cortex, and reelin expression was decreased in hippocampus from levels in controls without maternal thromboxane exposure. No significant differences in NCAM expression were seen in hippocampus, nor did reelin expression differ in cerebral cortex between control and IUGR groups. We also examined expression of two neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). In cerebral cortex the IUGR group showed less BDNF and NT-3 expression than controls. Delay of neuronal migration and histological changes observed in our IUGR rats may be related to altered expression of these molecules. FAU - Fukami, E AU - Fukami E AD - Department of Pediatrics, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya, Japan. eiko@tsuru.nagoya-u.ac.jp FAU - Nakayama, A AU - Nakayama A FAU - Sasaki, J AU - Sasaki J FAU - Mimura, S AU - Mimura S FAU - Mori, N AU - Mori N FAU - Watanabe, K AU - Watanabe K LA - eng PT - Journal Article PL - Ireland TA - Early Hum Dev JT - Early human development JID - 7708381 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 0 (Neural Cell Adhesion Molecules) RN - 0 (Neurotrophin 3) RN - 0 (RNA, Messenger) RN - 0 (Reelin Protein) RN - 0 (Reln protein, rat) RN - 57576-52-0 (Thromboxane A2) SB - IM MH - Animals MH - Brain/*metabolism MH - Brain-Derived Neurotrophic Factor/genetics MH - Cerebral Cortex/metabolism MH - Female MH - Fetal Growth Retardation/chemically induced/*metabolism MH - *Gene Expression MH - Hippocampus/metabolism MH - Nerve Growth Factors/*genetics MH - Neural Cell Adhesion Molecules/*genetics MH - Neurotrophin 3/genetics MH - Pregnancy MH - RNA, Messenger/analysis MH - Rats MH - Rats, Sprague-Dawley MH - Reelin Protein MH - Reverse Transcriptase Polymerase Chain Reaction MH - *Thromboxane A2 EDAT- 2000/06/16 09:00 MHDA- 2000/08/06 11:00 CRDT- 2000/06/16 09:00 PHST- 2000/06/16 09:00 [pubmed] PHST- 2000/08/06 11:00 [medline] PHST- 2000/06/16 09:00 [entrez] AID - S0378-3782(00)00068-2 [pii] AID - 10.1016/s0378-3782(00)00068-2 [doi] PST - ppublish SO - Early Hum Dev. 2000 May;58(2):101-10. doi: 10.1016/s0378-3782(00)00068-2.