PMID- 10855120
OWN - NLM
STAT- MEDLINE
DCOM- 20000803
LR  - 20191104
IS  - 1042-895X (Print)
IS  - 1042-895X (Linking)
VI  - 22
IP  - 6
DP  - 1999 Nov-Dec
TI  - Anti-TNF alpha: new therapy for Crohn's disease.
PG  - 245-8
AB  - Immunological technology has paved the way for a promising new therapy for 
      patients suffering from chronic active Crohn's disease. Neutralization of tumor 
      necrosis factor-alpha (TNF alpha), a cytokine secreted by cells in the immune 
      system, may prove useful in decreasing bowel inflammation and aid in the closure 
      of fistulae. Two multicenter, randomized, double-blinded, placebo-controlled 
      trials were conducted to evaluate the safety and efficacy of inflixmab (Remicade 
      [Centocor]), a chimeric monoclonal antibody form of anti-TNF alpha, hypothesized 
      to provide a prolonged therapeutic effect in chronic inflammation. The 5 mg/kg 
      dose regimen of infliximab was the lowest effective dose and produced a high 
      degree of benefit lasting 8 weeks to 3 months. Infusion preparation, cost, and 
      patient indications bear special considerations. Further investigation is needed 
      in long-term safety and efficacy for chronic administration of infliximab.
FAU - Mikula, C A
AU  - Mikula CA
AD  - Specialty Care Systems, Inc., Park Ridge, Illinois 60068, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Gastroenterol Nurs
JT  - Gastroenterology nursing : the official journal of the Society of 
      Gastroenterology Nurses and Associates
JID - 8915377
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Gastrointestinal Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - B72HH48FLU (Infliximab)
MH  - Antibodies, Monoclonal/immunology/pharmacology/*therapeutic use
MH  - Crohn Disease/immunology/*therapy
MH  - Drug Monitoring/methods/nursing
MH  - Gastrointestinal Agents/immunology/pharmacology/*therapeutic use
MH  - Humans
MH  - Infliximab
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/*immunology
RF  - 10
EDAT- 2000/06/16 09:00
MHDA- 2000/08/06 11:00
CRDT- 2000/06/16 09:00
PHST- 2000/06/16 09:00 [pubmed]
PHST- 2000/08/06 11:00 [medline]
PHST- 2000/06/16 09:00 [entrez]
AID - 10.1097/00001610-199911000-00004 [doi]
PST - ppublish
SO  - Gastroenterol Nurs. 1999 Nov-Dec;22(6):245-8. doi: 
      10.1097/00001610-199911000-00004.