PMID- 10855891
OWN - NLM
STAT- MEDLINE
DCOM- 20000629
LR  - 20190915
IS  - 0301-620X (Print)
IS  - 0301-620X (Linking)
VI  - 82
IP  - 4
DP  - 2000 May
TI  - The effects of the concentration of high-density polyethylene particles on the 
      bone-implant interface.
PG  - 595-600
AB  - We used a rat model in vivo to study the effects of the concentration of 
      polyethylene particles on the bone-implant interface around stable implants in 
      the proximal tibia. Intra-articular injections of 10(4), 10(6) or 10(8) 
      high-density polyethylene (HDPE) particles per joint were given 8, 10 and 12 
      weeks after surgery. The animals were killed after 14 and 26 weeks and the 
      response at the interface determined. Fibrous tissue was seen at the bone-implant 
      interface when the head of the implant was flush with the top of the tibia but 
      not when it was sunk below the tibial plateau. In the latter case the implant was 
      completely surrounded by a shell of bone. The area of fibrous tissue and that of 
      the gap between the implant and bone was related to the concentration of 
      particles in the 14-week group (p < 0.05). Foreign-body granulomas containing 
      HDPE particles were seen at the bone-implant interface in animals given 10(8) 
      particles. The pathology resembles that seen around prostheses with aseptic 
      loosening and we suggest that this is a useful model by which to study this 
      process.
FAU - Brooks, R A
AU  - Brooks RA
AD  - Orthopaedic Research Unit, University of Cambridge, Addenbrooke's Hospital, 
      Cambridge, UK.
FAU - Sharpe, J R
AU  - Sharpe JR
FAU - Wimhurst, J A
AU  - Wimhurst JA
FAU - Myer, B J
AU  - Myer BJ
FAU - Dawes, E N
AU  - Dawes EN
FAU - Rushton, N
AU  - Rushton N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Bone Joint Surg Br
JT  - The Journal of bone and joint surgery. British volume
JID - 0375355
RN  - 9002-88-4 (Polyethylene)
SB  - IM
MH  - Animals
MH  - Ceramics/adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Granuloma, Foreign-Body/enzymology/etiology/pathology
MH  - Histocytochemistry
MH  - Implants, Experimental/*adverse effects
MH  - Male
MH  - Particle Size
MH  - Polyethylene/administration & dosage/*pharmacology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tibia/*drug effects/enzymology/pathology
MH  - Time Factors
EDAT- 2000/06/16 09:00
MHDA- 2000/07/06 11:00
CRDT- 2000/06/16 09:00
PHST- 2000/06/16 09:00 [pubmed]
PHST- 2000/07/06 11:00 [medline]
PHST- 2000/06/16 09:00 [entrez]
AID - 10.1302/0301-620x.82b4.9744 [doi]
PST - ppublish
SO  - J Bone Joint Surg Br. 2000 May;82(4):595-600. doi: 10.1302/0301-620x.82b4.9744.