PMID- 10856443
OWN - NLM
STAT- MEDLINE
DCOM- 20000810
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 398
IP  - 1
DP  - 2000 Jun 9
TI  - Rapid and transient inhibition of mitochondrial function following 
      methamphetamine or 3,4-methylenedioxymethamphetamine administration.
PG  - 11-8
AB  - Metabolic mapping of discrete brain regions using cytochrome oxidase 
      histochemistry was used as a marker for alterations in mitochondrial function and 
      cytochrome oxidase enzymatic activity in response to high doses of amphetamine 
      derivatives. The activity of cytochrome oxidase, complex IV of the electron 
      transport chain, was determined at three different time-points following 
      administration of high doses of methamphetamine or 
      3,4-methylenedioxymethamphetamine (MDMA) (four injections of 10-15 mg/kg 
      administered over 8 h). There was a rapid decrease in cytochrome oxidase staining 
      in the striatum (23-29%), nucleus accumbens (29-30%) and substantia nigra 
      (31-43%), 2 h following administration of either methamphetamine and MDMA. This 
      decrease in cytochrome oxidase activity was transient and returned to control 
      levels within 24 h. Since the methamphetamine and MDMA-induced decrease in 
      cytochrome oxidase activity was localized to dopamine-rich regions, increased 
      extracellular concentrations of dopamine may contribute to the inhibition of 
      metabolic function via its metabolism to form quinones or other reactive oxygen 
      species. These results support previous studies demonstrating that 
      psychostimulants induce a rapid and transient decrease in striatal ATP stores and 
      provide further evidence that these drugs of abuse can disrupt mitochondrial 
      function.
FAU - Burrows, K B
AU  - Burrows KB
AD  - Program in Basic and Clinical Neuroscience, Department of Psychiatry, Case 
      Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
FAU - Gudelsky, G
AU  - Gudelsky G
FAU - Yamamoto, B K
AU  - Yamamoto BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 44RAL3456C (Methamphetamine)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/*pharmacology
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Brain/drug effects/enzymology
MH  - Brain Mapping
MH  - Dopamine Uptake Inhibitors/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Electron Transport Complex IV/drug effects/metabolism
MH  - Male
MH  - Methamphetamine/*pharmacology
MH  - Mitochondria/*drug effects/enzymology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 2000/06/17 09:00
MHDA- 2000/08/12 11:00
CRDT- 2000/06/17 09:00
PHST- 2000/06/17 09:00 [pubmed]
PHST- 2000/08/12 11:00 [medline]
PHST- 2000/06/17 09:00 [entrez]
AID - S0014-2999(00)00264-8 [pii]
AID - 10.1016/s0014-2999(00)00264-8 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2000 Jun 9;398(1):11-8. doi: 10.1016/s0014-2999(00)00264-8.