PMID- 10857846
OWN - NLM
STAT- MEDLINE
DCOM- 20000706
LR  - 20220408
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 67
IP  - 6
DP  - 2000 Jun
TI  - Interleukin-16.
PG  - 757-66
AB  - Interleukin 16 (IL-16) was initially described in 1982 as the first T cell 
      chemoattractant. Through interaction with CD4, IL-16 has now been characterized 
      as a chemoattractant for a variety of CD4+ immune cells. Recent in vivo studies 
      have more fully characterized IL-16 as an immunomodulatory cytokine that 
      contributes to the regulatory process of CD4+ cell recruitment and activation at 
      sites of inflammation in association with asthma and several autoimmune diseases. 
      Since its cloning in 1994, IL-16 structure and function have been studied 
      extensively. This review addresses the current data regarding IL-16 protein and 
      gene structure; the expanding list of cells capable of generating IL-16; the 
      direct interaction of IL-16 with its receptor, CD4; and the functional 
      bioactivities of IL-16 as they relate to inflammation and HIV-1 infection. In 
      addition, potential therapeutic modalities for IL-16 relating to inflammation and 
      immune reconstitution in HIV-1 infection are also discussed.
FAU - Cruikshank, W W
AU  - Cruikshank WW
AD  - Pulmonary Center, Boston University School of Medicine, Massachusetts 02118, USA. 
      bcruikshank@bupula.bu.edu
FAU - Kornfeld, H
AU  - Kornfeld H
FAU - Center, D M
AU  - Center DM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (CD4 Antigens)
RN  - 0 (Interleukin-16)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - CD4 Antigens/immunology
MH  - HIV Infections/immunology
MH  - HIV-1/immunology
MH  - Humans
MH  - Interleukin-16/chemistry/genetics/*immunology
MH  - Protein Structure, Tertiary
MH  - RNA, Messenger
MH  - Signal Transduction/immunology
RF  - 82
EDAT- 2000/06/17 09:00
MHDA- 2000/07/08 11:00
CRDT- 2000/06/17 09:00
PHST- 2000/06/17 09:00 [pubmed]
PHST- 2000/07/08 11:00 [medline]
PHST- 2000/06/17 09:00 [entrez]
AID - 10.1002/jlb.67.6.757 [doi]
PST - ppublish
SO  - J Leukoc Biol. 2000 Jun;67(6):757-66. doi: 10.1002/jlb.67.6.757.