PMID- 10858986
OWN - NLM
STAT- MEDLINE
DCOM- 20001027
LR  - 20190822
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 55
IP  - 6
DP  - 2000 Jun
TI  - Severe atopic dermatitis is associated with sensitization to staphylococcal 
      enterotoxin B (SEB).
PG  - 551-5
AB  - BACKGROUND: Staphylococcus aureus has been identified as a possible trigger 
      factor in atopic dermatitis (AD). Some 30-60% of S. aureus strains isolated from 
      patients with AD are able to produce exotoxins with superantigenic properties, 
      mostly staphylococcal enterotoxins A, B, C, and D (SEA-D) and toxic shock 
      syndrome toxin-1 (TSST-1). Recently, it was demonstrated that the presence of IgE 
      antibodies to SEA and SEB is correlated with the severity of skin lesions in 
      children with AD. To determine the relevance of staphylococcal enterotoxins in 
      adult patients with AD, we investigated the relationship between the severity of 
      skin lesions and sensitization to SEA and SEB. METHODS: Clinical severity was 
      determined by the SCORAD index. Circulating IgE antibodies to SEA and SEB, serum 
      eosinophil cationic protein (ECP) levels, and urine eosinophil protein X (EPX) 
      levels were measured. RESULTS: The skin condition was significantly worse in 
      patients sensitized to SEB than in unsensitized patients. Serum ECP and urine EPX 
      levels were found to be significantly higher in SEB-sensitized patients, 
      confirming the higher degree of cutaneous inflammation. CONCLUSIONS: Our results 
      demonstrate a relationship between severity of skin lesions and sensitization to 
      SEB in adult patients with AD, but a relationship between disease activity and 
      sensitization to SEA could not be shown.
FAU - Breuer, K
AU  - Breuer K
AD  - Department of Dermatology and Allergology, Hannover Medical University, Germany.
FAU - Wittmann, M
AU  - Wittmann M
FAU - Bosche, B
AU  - Bosche B
FAU - Kapp, A
AU  - Kapp A
FAU - Werfel, T
AU  - Werfel T
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 0 (Blood Proteins)
RN  - 0 (Enterotoxins)
RN  - 0 (Eosinophil Granule Proteins)
RN  - 37337-57-8 (enterotoxin A, Staphylococcal)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 39424-53-8 (enterotoxin B, staphylococcal)
RN  - EC 3.1.- (Eosinophil-Derived Neurotoxin)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Allergens/immunology
MH  - Blood Proteins/analysis/urine
MH  - Dermatitis, Atopic/blood/*immunology/urine
MH  - Enterotoxins/*immunology
MH  - Eosinophil Granule Proteins
MH  - Eosinophil-Derived Neurotoxin
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Male
MH  - Ribonucleases/urine
MH  - Severity of Illness Index
EDAT- 2000/06/20 09:00
MHDA- 2001/02/28 10:01
CRDT- 2000/06/20 09:00
PHST- 2000/06/20 09:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/06/20 09:00 [entrez]
AID - 10.1034/j.1398-9995.2000.00432.x [doi]
PST - ppublish
SO  - Allergy. 2000 Jun;55(6):551-5. doi: 10.1034/j.1398-9995.2000.00432.x.