PMID- 10859416
OWN - NLM
STAT- MEDLINE
DCOM- 20000824
LR  - 20220318
IS  - 1420-3030 (Print)
IS  - 1420-3030 (Linking)
VI  - 5
IP  - 3-4
DP  - 2000 May-Aug
TI  - Mismatch negativity in aging and in Alzheimer's and Parkinson's diseases.
PG  - 216-24
AB  - Mismatch negativity (MMN) is an auditory event-related potential (ERP) that 
      reflects automatic stimulus discrimination in the human auditory system. By 
      varying the interstimulus intervals (ISIs), the MMN can be used as an index of 
      auditory sensory memory. This paper focuses on MMN findings in aging and in 
      Alzheimer's (AD) and Parkinson's diseases (PD). The accumulated data suggest that 
      MMN to duration deviance, unlike MMN to frequency deviance, is reduced in 
      amplitude in aging at short ISIs. The attenuated MMN to frequency deviance 
      observed at long ISIs in elderly subjects seems to be caused by age-related 
      memory trace decay. Existing results suggest that automatic discrimination for 
      the frequency change is not affected in the early phase of AD, whereas the memory 
      trace seems to decay faster in AD patients. The present findings on PD are not as 
      conclusive, although they tentatively suggest deteriorated automatic change 
      detection. The MMN appears to offer an objective tool for studying auditory 
      processing and memory trace decay in different neurological disorders.
CI  - Copyright 2000 S. Karger AG, Basel
FAU - Pekkonen, E
AU  - Pekkonen E
AD  - Department of Neurology, Helsinki University Central Hospital, Finland. 
      eero@biomag.helsinki.fi
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Audiol Neurootol
JT  - Audiology & neuro-otology
JID - 9606930
SB  - IM
MH  - Aged
MH  - Aging/*physiology
MH  - Alzheimer Disease/diagnosis/*physiopathology
MH  - Auditory Cortex/physiopathology
MH  - Brain Mapping
MH  - Contingent Negative Variation/*physiology
MH  - Evoked Potentials, Auditory/*physiology
MH  - Humans
MH  - Mental Recall/physiology
MH  - Parkinson Disease/diagnosis/*physiopathology
MH  - Reference Values
RF  - 60
EDAT- 2000/06/22 10:00
MHDA- 2000/08/29 11:01
CRDT- 2000/06/22 10:00
PHST- 2000/06/22 10:00 [pubmed]
PHST- 2000/08/29 11:01 [medline]
PHST- 2000/06/22 10:00 [entrez]
AID - 13883 [pii]
AID - 10.1159/000013883 [doi]
PST - ppublish
SO  - Audiol Neurootol. 2000 May-Aug;5(3-4):216-24. doi: 10.1159/000013883.