PMID- 10859649
OWN - NLM
STAT- MEDLINE
DCOM- 20000710
LR  - 20041117
IS  - 0306-9877 (Print)
IS  - 0306-9877 (Linking)
VI  - 54
IP  - 4
DP  - 2000 Apr
TI  - Statistico-mechanics of chromosomal insertions in human cancers.
PG  - 616-8
AB  - The paper discusses a mechanism for segmental insertions (ins) between two 
      chromatids. In human cancers, such rearrangements are significantly less frequent 
      than reciprocal translocations (rt). Regarding the clinical incidence of ins 
      versus rt, the proposed dynamics is more satisfactory than the random mutation 
      hypothesis.
CI  - Copyright 2000 Harcourt Publishers Ltd.
FAU - Matioli, G T
AU  - Matioli GT
AD  - USC Medical School, Los Angeles, CA 90033, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
SB  - IM
MH  - *Chromosome Aberrations
MH  - Humans
MH  - Neoplasms/*genetics
MH  - *Translocation, Genetic
EDAT- 2000/06/22 10:00
MHDA- 2000/07/15 11:00
CRDT- 2000/06/22 10:00
PHST- 2000/06/22 10:00 [pubmed]
PHST- 2000/07/15 11:00 [medline]
PHST- 2000/06/22 10:00 [entrez]
AID - S0306-9877(99)90906-4 [pii]
AID - 10.1054/mehy.1999.0906 [doi]
PST - ppublish
SO  - Med Hypotheses. 2000 Apr;54(4):616-8. doi: 10.1054/mehy.1999.0906.