PMID- 10860687
OWN - NLM
STAT- MEDLINE
DCOM- 20000809
LR  - 20061115
IS  - 0195-6701 (Print)
IS  - 0195-6701 (Linking)
VI  - 45
IP  - 2
DP  - 2000 Jun
TI  - Role of infection control measures in limiting morbidity associated with 
      multi-resistant organisms in critically ill patients.
PG  - 107-16
AB  - A retrospective comparative study was performed to determine the impact of 
      infection control measures (ICMs) on colonization and infections due to 
      methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae 
      (producing transferable extended-spectrum beta-lactamase, KPESBL), and 
      multi-resistant Enterobacter aerogenes (MREA) in intensive care unit patients. 
      Infection Control Measures included surveillance cultures, isolation procedures 
      and mupirocin for MRSA nasal carriage. The numbers of patients infected and/or 
      colonized by MRSA, KPESBL or MREA were compared during two consecutive one-year 
      periods (Period 1 before ICMs, and Period 2 after ICMs). The antibiotic 
      consumption during the two periods was analysed. In Period 1 and Period 2, 
      respectively, the rate of patients infected or colonized by at least one of the 
      three organisms was 15% and 6.8% (P=0.001); by MRSA 7.7% and 2.6% (P=0. 004); by 
      KPESBL 1.7% and 0% (P=0.25); and by MREA 5.6% and 4.3% (P=0. 47). During Period 
      2, there was a clear-cut decrease in the percentage of patients infected by MRSA 
      (P=0.018), a non-significant decrease in those infected by KPESBL (P=0.06), and 
      no decrease in patients infected by MREA (P=0.22). When calculated per 1000 
      patient-days, for Period 1 and Period 2, respectively, the rate of patients 
      infected or colonized by at least one of the three organisms was 11.9 and 8.8; 
      for MRSA it was 4 and 2.2; for KPESBL it was 1 and 0; and for MREA it was 4 and 
      4. Antibiotic cost was pound98.7 in Period 1 and pound62.7 in Period 2. ICMs 
      contributed to the control of infections and colonizations due to MRSA and KPESBL 
      but not those due to MREA.
CI  - Copyright 2000 The Hospital Infection Society.
FAU - Souweine, B
AU  - Souweine B
AD  - Service de Reanimation Medicale Polyvalente, Clermont-Ferrand, France.
FAU - Traore, O
AU  - Traore O
FAU - Aublet-Cuvelier, B
AU  - Aublet-Cuvelier B
FAU - Bret, L
AU  - Bret L
FAU - Sirot, J
AU  - Sirot J
FAU - Laveran, H
AU  - Laveran H
FAU - Deteix, P
AU  - Deteix P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hosp Infect
JT  - The Journal of hospital infection
JID - 8007166
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Aged
MH  - Anti-Bacterial Agents/economics/therapeutic use
MH  - Bacterial Infections/microbiology/*prevention & control
MH  - Drug Costs
MH  - *Drug Resistance, Multiple
MH  - Enterobacteriaceae Infections/epidemiology/prevention & control
MH  - Female
MH  - France/epidemiology
MH  - Humans
MH  - Infection Control/*methods
MH  - *Intensive Care Units
MH  - Klebsiella Infections/epidemiology/prevention & control
MH  - Klebsiella pneumoniae
MH  - Male
MH  - Methicillin Resistance
MH  - Retrospective Studies
MH  - Staphylococcal Infections/epidemiology/prevention & control
MH  - beta-Lactam Resistance
EDAT- 2000/06/22 10:00
MHDA- 2000/08/12 11:00
CRDT- 2000/06/22 10:00
PHST- 2000/06/22 10:00 [pubmed]
PHST- 2000/08/12 11:00 [medline]
PHST- 2000/06/22 10:00 [entrez]
AID - S0195-6701(00)90734-5 [pii]
AID - 10.1053/jhin.2000.0734 [doi]
PST - ppublish
SO  - J Hosp Infect. 2000 Jun;45(2):107-16. doi: 10.1053/jhin.2000.0734.