PMID- 10861018 OWN - NLM STAT- MEDLINE DCOM- 20000731 LR - 20220318 IS - 0027-8424 (Print) IS - 1091-6490 (Electronic) IS - 0027-8424 (Linking) VI - 97 IP - 13 DP - 2000 Jun 20 TI - Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior. PG - 7551-5 AB - Steroid hormone action during brain development exerts profound effects on reproductive physiology and behavior that last into adulthood. A variety of in vitro studies indicate that steroid receptors require nuclear receptor coactivators for efficient transcriptional activity. To determine the functional significance of the nuclear receptor coactivator SRC-1 in developing brain, we investigated the consequence of reducing SRC-1 protein during sexual differentiation of the brain. We report that reducing SRC-1 protein interferes with the defeminizing actions of estrogen in neonatal rat brain. Our data indicate that SRC-1 protein expression is critically involved in the hormone-dependent development of normal male reproductive behavior and brain morphology. FAU - Auger, A P AU - Auger AP AD - Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA. aauge001@umaryland.edu FAU - Tetel, M J AU - Tetel MJ FAU - McCarthy, M M AU - McCarthy MM LA - eng GR - R29 MH052716/MH/NIMH NIH HHS/United States GR - HD08618/HD/NICHD NIH HHS/United States GR - F32 HD008618/HD/NICHD NIH HHS/United States GR - MH52716/MH/NIMH NIH HHS/United States GR - R01 MH052716/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Proc Natl Acad Sci U S A JT - Proceedings of the National Academy of Sciences of the United States of America JID - 7505876 RN - 0 (Trans-Activators) RN - 0 (Transcription Factors) RN - EC 2.3.1.48 (Histone Acetyltransferases) RN - EC 2.3.1.48 (Nuclear Receptor Coactivator 1) SB - IM MH - Animals MH - Brain/cytology/embryology/*physiology MH - Female MH - Gene Expression Regulation, Developmental/physiology MH - Histone Acetyltransferases MH - Male MH - Nuclear Receptor Coactivator 1 MH - Rats MH - Rats, Sprague-Dawley MH - Sexual Behavior, Animal/*physiology MH - Trans-Activators/physiology MH - Transcription Factors/*physiology PMC - PMC16583 EDAT- 2000/06/22 10:00 MHDA- 2000/08/06 11:00 PMCR- 2000/12/20 CRDT- 2000/06/22 10:00 PHST- 2000/06/22 10:00 [pubmed] PHST- 2000/08/06 11:00 [medline] PHST- 2000/06/22 10:00 [entrez] PHST- 2000/12/20 00:00 [pmc-release] AID - 97/13/7551 [pii] AID - 0901 [pii] AID - 10.1073/pnas.97.13.7551 [doi] PST - ppublish SO - Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7551-5. doi: 10.1073/pnas.97.13.7551.