PMID- 10862059
OWN - NLM
STAT- MEDLINE
DCOM- 20000815
LR  - 20190915
IS  - 1053-1807 (Print)
IS  - 1053-1807 (Linking)
VI  - 11
IP  - 6
DP  - 2000 Jun
TI  - Magnetic resonance imaging of regional myocardial perfusion in patients with 
      single-vessel coronary artery disease: quantitative comparison with 
      (201)Thallium-SPECT and coronary angiography.
PG  - 607-15
AB  - The clinical value of magnetic resonance perfusion imaging (MRI) was investigated 
      by quantitative comparison with (201)thallium-single-photon emission computed 
      tomography ((201)TI-SPECT) and quantitative coronary angiography (QCA). 
      Short-axis imaging was performed during dipyridamole administration in 13 
      patients with single-vessel coronary artery disease. Using inner and outer 
      contours, the myocardium was divided into 30 contiguous, radial regions. Defining 
      a perfusion defect as a region with less than 90% of maximum (201)TI intensity, 
      nine patients had a matching perfusion defect, two had no defect on both 
      (201)TI-SPECT or MRI, and one had a defect on (201)TI-SPECT but not on MRI. One 
      patient had a defect on both modalities but with inaccurate localization. Three 
      perfusion parameters were investigated: a) maximum contrast enhancement (MCE); b) 
      slope of the signal intensity versus time curve; and c) inverse mean transit time 
      (1/MTT). The sensitivity and specificity of MCE in the detection of perfusion 
      abnormalities with TI-SPECT as the reference method were 71% and 71%, 
      respectively (slope 77% and 61%, 1/MTT 44% and 70%). Furthermore, correlations 
      were calculated per patient for the entire circumference of the short-axis 
      myocardium. Median correlations were as follows: MCE 0.92, slope 0.91, and 1/MTT 
      0.40. Mismatches between (201)TI defects and defects on MRI resulted in low mean 
      correlations (MCE 0.45, slope 0.46, and 1/MTT 0.26). There was a trend between 
      severity of perfusion defects on MRI (using MCE) and QCA stenosis area (r = 
      -0.56, P = 0.06). Thus, MRI and (201)TI-SPECT demonstrate fair agreement in the 
      assessment of perfusion defects but show moderate correlation when the entire 
      short-axis myocardium is correlated.
CI  - Copyright 2000 Wiley-Liss, Inc.
FAU - Keijer, J T
AU  - Keijer JT
AD  - Department of Cardiology, Free University Hospital, 1007 MB Amsterdam, 
      Interuniversity Cardiology Institute (ICIN), 3511 GC Utrecht, The Netherlands.
FAU - van Rossum, A C
AU  - van Rossum AC
FAU - van Eenige, M J
AU  - van Eenige MJ
FAU - Bax, J J
AU  - Bax JJ
FAU - Visser, F C
AU  - Visser FC
FAU - Teule, J J
AU  - Teule JJ
FAU - Visser, C A
AU  - Visser CA
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Thallium Radioisotopes)
SB  - IM
MH  - Aged
MH  - Coronary Angiography/*methods
MH  - Coronary Disease/*diagnosis
MH  - Coronary Vessels/*diagnostic imaging/*pathology
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/pathology
MH  - Sensitivity and Specificity
MH  - Thallium Radioisotopes
MH  - Tomography, Emission-Computed, Single-Photon/methods
EDAT- 2000/06/22 10:00
MHDA- 2000/08/19 11:00
CRDT- 2000/06/22 10:00
PHST- 2000/06/22 10:00 [pubmed]
PHST- 2000/08/19 11:00 [medline]
PHST- 2000/06/22 10:00 [entrez]
AID - 10.1002/1522-2586(200006)11:6<607::AID-JMRI6>3.0.CO;2-7 [pii]
AID - 10.1002/1522-2586(200006)11:6<607::aid-jmri6>3.0.co;2-7 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2000 Jun;11(6):607-15. doi: 
      10.1002/1522-2586(200006)11:6<607::aid-jmri6>3.0.co;2-7.