PMID- 10862076
OWN - NLM
STAT- MEDLINE
DCOM- 20000830
LR  - 20191210
IS  - 1057-9230 (Print)
IS  - 1057-9230 (Linking)
VI  - 9
IP  - 4
DP  - 2000 Jun
TI  - Fieller's method and net health benefits.
PG  - 327-35
AB  - Statistical and conceptual difficulties complicate the estimation of the 
      incremental cost-effectiveness ratio (ICER). An alternative approach is to 
      measure cost-effectiveness by the incremental net health benefit (INHB), defined 
      as the difference in mean effectiveness of a new treatment compared with a 
      standard, adjusted for cost difference by subtracting the health foregone if 
      purchasing care at the rate of a marginally cost-effective therapy. Because net 
      health benefit (NHB) is dependent on this threshold rate, one can construct 
      confidence intervals for the INHB at various values of the rate. It turns out 
      that the set of rates where new and standard are not significantly different is 
      equal to the Fieller's method confidence set for the ICER. We review the 
      derivation of the Fieller's method confidence set, present numerical examples, 
      and discuss the implications of our result for the calculation and interpretation 
      of NHB analyses.
CI  - Copyright 2000 John Wiley & Sons, Ltd.
FAU - Heitjan, D F
AU  - Heitjan DF
AD  - Division of Biostatistics, Columbia University, New York 10032, USA. 
      dfh5@columbia.edu
LA  - eng
GR  - HL-53968/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Health Econ
JT  - Health economics
JID - 9306780
SB  - IM
MH  - Bayes Theorem
MH  - Clinical Trials as Topic
MH  - *Confidence Intervals
MH  - Cost-Benefit Analysis/*methods/statistics & numerical data
MH  - Health Services Research/economics/*methods
MH  - Humans
MH  - Models, Economic
MH  - Outcome Assessment, Health Care/*statistics & numerical data
EDAT- 2000/06/22 10:00
MHDA- 2000/09/02 11:01
CRDT- 2000/06/22 10:00
PHST- 2000/06/22 10:00 [pubmed]
PHST- 2000/09/02 11:01 [medline]
PHST- 2000/06/22 10:00 [entrez]
AID - 10.1002/1099-1050(200006)9:4<327::AID-HEC517>3.0.CO;2-S [pii]
AID - 10.1002/1099-1050(200006)9:4<327::aid-hec517>3.0.co;2-s [doi]
PST - ppublish
SO  - Health Econ. 2000 Jun;9(4):327-35. doi: 
      10.1002/1099-1050(200006)9:4<327::aid-hec517>3.0.co;2-s.