PMID- 10862714
OWN - NLM
STAT- MEDLINE
DCOM- 20000918
LR  - 20220408
IS  - 0021-9533 (Print)
IS  - 0021-9533 (Linking)
VI  - 113 ( Pt 14)
DP  - 2000 Jul
TI  - The role of retinoic acid receptors in neurite outgrowth from different 
      populations of embryonic mouse dorsal root ganglia.
PG  - 2567-74
AB  - Dorsal root ganglion (DRG) neurons can be categorised into at least three types, 
      based upon their neurotrophin requirement for survival. We have analysed the 
      expression of the retinoic acid receptors (RARs) and the retinoid X receptors 
      (RXRs) in NGF, NT-3 and BDNF dependent neurons isolated from embryonic day 
      (E)13.5 mouse DRG. We show that each population of neurons expressed each of the 
      three RXRs, (alpha), (beta) and (gamma); however, whilst the NGF and NT-3 
      dependent neurons expressed each of the RARs (alpha), (beta) and (gamma), the 
      BDNF dependent neurons only expressed RAR(alpha) and (beta). When retinoic acid 
      was added to each of the neuronal classes only the NGF and NT-3 dependent neurons 
      responded by extending neurites, and this response involved the upregulation of 
      RAR(beta)(2). This specificity was confirmed by the use of receptor-selective 
      agonists as only a RAR(beta)-selective compound stimulated neurite outgrowth. 
      These results suggest a role for RA acting via RAR(beta)(2) in the outgrowth of 
      neurites.
FAU - Corcoran, J
AU  - Corcoran J
AD  - Developmental Biology Research Centre, The Randall Institute, King's College 
      London, London, WC2B 5RL, UK. jonathan.corcoran@kcl.ac.uk
FAU - Shroot, B
AU  - Shroot B
FAU - Pizzey, J
AU  - Pizzey J
FAU - Maden, M
AU  - Maden M
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Cell Sci
JT  - Journal of cell science
JID - 0052457
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Protein Isoforms)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Ganglia, Spinal/drug effects/embryology/*physiology
MH  - Gene Expression/drug effects/physiology
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Mice
MH  - Nerve Growth Factors/pharmacology
MH  - Neurites/drug effects/*physiology
MH  - Neurons/drug effects/physiology
MH  - Protein Isoforms/drug effects/metabolism/physiology
MH  - Receptors, Retinoic Acid/drug effects/metabolism/*physiology
MH  - Retinoid X Receptors
MH  - Transcription Factors/drug effects/metabolism/*physiology
MH  - Tretinoin/analogs & derivatives/pharmacology
EDAT- 2000/06/23 00:00
MHDA- 2000/09/23 00:00
CRDT- 2000/06/23 00:00
PHST- 2000/06/23 00:00 [pubmed]
PHST- 2000/09/23 00:00 [medline]
PHST- 2000/06/23 00:00 [entrez]
AID - 10.1242/jcs.113.14.2567 [doi]
PST - ppublish
SO  - J Cell Sci. 2000 Jul;113 ( Pt 14):2567-74. doi: 10.1242/jcs.113.14.2567.