PMID- 10862948
OWN - NLM
STAT- MEDLINE
DCOM- 20000720
LR  - 20190826
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 112
IP  - 1-2
DP  - 2000 Jul
TI  - Learning performances, brain NGF distribution and NPY levels in transgenic mice 
      expressing TNF-alpha.
PG  - 165-75
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a cytokine involved in a variety of 
      neurobiological activities including changing behavior and regulation of both 
      neurotrophin and neuropeptide levels. In this study we used two lines of 
      transgenic mice overexpressing brain TNF-alpha characterized by neurological 
      deficits (line Tg6074) or phenotypically normal (line TgK3). We analyzed whether 
      or not impairments in learning and memory processes due to TNF-alpha 
      overexpression were associated with changes in endogenous brain NGF, NPY and 
      beta-amyloid. The results indicate that full TNF-alpha transgene expression 
      disrupted the learning capabilities of transgenic mice (both Tg6074 and TgK3). 
      NGF decreased in the hippocampus of both transgenic mice whereas hippocampal NPY 
      slightly potentiated in Tg6074. The decrease in NGF is correlated with deficits 
      in spatial learning and memory whereas inflammation in the brain of Tg6074 could 
      be responsible of the hippocampal increase in NPY. As a whole, these results show 
      that transgenic mice overexpressing TNF-alpha in the brain represent a useful 
      model for studying neuronal degeneration and brain inflammatory processes.
FAU - Fiore, M
AU  - Fiore M
AD  - Institute of Neurobiology, CNR, viale Marx, 15, 00137, Rome, Italy.
FAU - Angelucci, F
AU  - Angelucci F
FAU - Alleva, E
AU  - Alleva E
FAU - Branchi, I
AU  - Branchi I
FAU - Probert, L
AU  - Probert L
FAU - Aloe, L
AU  - Aloe L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Amyloid beta-Peptides/*metabolism
MH  - Animals
MH  - Disease Models, Animal
MH  - Female
MH  - Gene Expression
MH  - Hippocampus/*metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Maze Learning/*physiology
MH  - Memory/*physiology
MH  - Mice
MH  - Mice, Transgenic
MH  - Nerve Growth Factor/*metabolism
MH  - Neurodegenerative Diseases/metabolism/*physiopathology
MH  - Neuropeptide Y/*metabolism
MH  - Radioimmunoassay
MH  - Swimming
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2000/06/23 11:00
MHDA- 2000/07/25 11:00
CRDT- 2000/06/23 11:00
PHST- 2000/06/23 11:00 [pubmed]
PHST- 2000/07/25 11:00 [medline]
PHST- 2000/06/23 11:00 [entrez]
AID - S0166432800001807 [pii]
AID - 10.1016/s0166-4328(00)00180-7 [doi]
PST - ppublish
SO  - Behav Brain Res. 2000 Jul;112(1-2):165-75. doi: 10.1016/s0166-4328(00)00180-7.