PMID- 10863031
OWN - NLM
STAT- MEDLINE
DCOM- 20000901
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 287
IP  - 3
DP  - 2000 Jun 30
TI  - Intracerebroventricular administration of brain-derived neurotrophic factor in 
      adult rats affects analgesia and spontaneous behaviour but not memory retention 
      in a Morris Water Maze task.
PG  - 207-10
AB  - The present study tested the effects of in vivo administration of brain-derived 
      neurotrophic factor (BDNF) and of its antibody (anti-BDNF) in a Morris Water Maze 
      (MWM) task. Adult male rats were trained for three days in a MWM. At the end of 
      the last training trial, subjects were injected intracerebroventricularly with 
      one of the following: (i) BDNF (24 microg); (ii) anti-BDNF (25 microg); or (iii) 
      vehicle (PBS, injection volume 10 microl). On day 5, subjects were tested for 
      memory retention, pain sensitivity and locomotor behaviour. No differences 
      emerged in the MWM as a function of treatment, even with a reduced number of 
      acquisition trials. Nonetheless, BDNF affected both pain threshold in the 
      hot-plate test, as well as exploratory behaviour in the open field test.
FAU - Cirulli, F
AU  - Cirulli F
AD  - Behavioural Pathophysiology Section, Istituto Superiore di Sanita, Rome, Italy.
FAU - Berry, A
AU  - Berry A
FAU - Alleva, E
AU  - Alleva E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Antibodies/pharmacology
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/immunology/*pharmacology
MH  - Hot Temperature
MH  - Injections, Intraventricular
MH  - Locomotion/drug effects
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Memory/drug effects
MH  - Neuronal Plasticity/drug effects
MH  - Nociceptors/drug effects
MH  - Pain Threshold/*drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2000/06/23 11:00
MHDA- 2000/09/09 11:01
CRDT- 2000/06/23 11:00
PHST- 2000/06/23 11:00 [pubmed]
PHST- 2000/09/09 11:01 [medline]
PHST- 2000/06/23 11:00 [entrez]
AID - S0304394000011733 [pii]
AID - 10.1016/s0304-3940(00)01173-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 2000 Jun 30;287(3):207-10. doi: 10.1016/s0304-3940(00)01173-3.