PMID- 10865419
OWN - NLM
STAT- MEDLINE
DCOM- 20000721
LR  - 20071115
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 83 Suppl 1
DP  - 2000 Mar
TI  - Preliminary study of HLA-ABCDR antigens in CML, ANLL, thalassemia and severe 
      aplastic anemia in Thais.
PG  - S130-6
AB  - The objective of this study was to analyse human leukocyte antigen (HLA) and 
      disease association in common blood diseases [chronic myelogenous leukemia (CML), 
      acute nonlymphocytic leukemia (ANLL), thalassemia and severe aplastic anemia] in 
      Thais. The subjects were patients from the Hematological Clinic, Departments of 
      Medicine and Pediatrics, Ramathibodi Hospital who were referred for HLA typing 
      for bone marrow transplantation (BMT) at the Histocompatibility Laboratory from 
      March 1988 to September 1997. A total of 129 patients had complete HLA-ABC 
      typing. The patients included 45 CML, 40 ANLL, 26 thalassemia (Thal) and 18 
      severe aplastic anemia (SAA). Of these, 88 patients were typed for HLA class II. 
      The HLA class I (ABC) and II (DR, DQ) typings were performed by 
      microlymphocytotoxicity test. It was found that HLA class I was associated with 
      CML, ANLL and Thal, whereas, HLA class II was associated with SAA. HLA-B8 and 
      HLA-B18 were increased in CML with R.R. values of 12.2 and 3.9, respectively, 
      whereas, HLA-B18 was increased in ANLL with R.R. value of 4.5. In addition, 
      HLA-DR2 and DR3 were increased in SAA with R.R. values of 3.8 and 4.8, 
      respectively. For Thal, HLA-A2 and B46 were increased in Thal in Central Thais 
      with R.R. values of 3.3 and 6.1, respectively, whereas, HLA-B13 was increased in 
      Thal in Northern Thais with R.R. value of 8.5. On the other hand, HLA-B7 was 
      absent in CML. HLA-Cw7 was decreased in CML and SAA, whereas, HLA-DR6 was 
      decreased in ANLL and SAA. Furthermore, HLA-Cw6 was also decreased in CML, 
      whereas, HLA-A33 and Bw4 were decreased in SAA. Although the sample size of each 
      disease was small, the increase of HLA-DR2 was observed in SAA in Thais which was 
      similar to other studies in different ethnic groups. These preliminary data may 
      be useful for further study in HLA and blood disease association.
FAU - Chiewsilp, P
AU  - Chiewsilp P
AD  - National Blood Centre, Thai Red Cross Society, Bangkok, Thailand.
FAU - Sujirachato, K
AU  - Sujirachato K
FAU - Mongkolsuk, T
AU  - Mongkolsuk T
FAU - Junpong, S
AU  - Junpong S
FAU - Jootar, S
AU  - Jootar S
FAU - Hathirat, P
AU  - Hathirat P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Anemia, Aplastic/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - HLA Antigens/*analysis
MH  - HLA-A Antigens/analysis
MH  - HLA-B Antigens/analysis
MH  - HLA-C Antigens/analysis
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*immunology
MH  - Leukemia, Myeloid, Acute/*immunology
MH  - Male
MH  - Probability
MH  - Reference Values
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - beta-Thalassemia/*immunology
EDAT- 2000/06/24 11:00
MHDA- 2000/08/01 11:00
CRDT- 2000/06/24 11:00
PHST- 2000/06/24 11:00 [pubmed]
PHST- 2000/08/01 11:00 [medline]
PHST- 2000/06/24 11:00 [entrez]
PST - ppublish
SO  - J Med Assoc Thai. 2000 Mar;83 Suppl 1:S130-6.