PMID- 10865885 OWN - NLM STAT- MEDLINE DCOM- 20000719 LR - 20031114 IS - 0019-5189 (Print) IS - 0019-5189 (Linking) VI - 37 IP - 12 DP - 1999 Dec TI - Effect of dietary fish on antioxidant parameters of normal and cholesterol stressed rats. PG - 1187-91 AB - Feeding fish (Sardinella longiceps) to normal rats increased lipid peroxidation and total and Se-dependent glutathione peroxidase (GSH-px) activity in erythrocytes and manganese dependent superoxide dismutase (Mn-SOD) activity in liver. Feeding fish to cholesterol stressed rats showed a significant increase in the activity of GSH-px and cholesterol feeding alone, resulted in a significant increase in the lipid peroxidation and liver Mn-SOD activity. The results suggest that the high polyunsaturated fatty acid content of S. longiceps, the fish abundantly available in the west coast of India, does not have any deleterious effect by way of free radical generation. The observed lipid peroxidation is not critical as is evident from the results of glutathione level and other scavenging enzymes. FAU - Nandini, M AU - Nandini M AD - Department of Biochemistry, Kasturba Medical College, Mangalore, India. FAU - Rahiman, M A AU - Rahiman MA FAU - Rao, S N AU - Rao SN LA - eng PT - Journal Article PL - India TA - Indian J Exp Biol JT - Indian journal of experimental biology JID - 0233411 RN - 0 (Antioxidants) RN - 0 (Cholesterol, Dietary) RN - 0 (Fish Oils) RN - EC 1.11.1.9 (Glutathione Peroxidase) RN - EC 1.15.1.1 (Superoxide Dismutase) SB - IM MH - Animals MH - Antioxidants/*metabolism MH - Cholesterol, Dietary/*administration & dosage MH - *Diet MH - Fish Oils/pharmacology MH - Fishes MH - Glutathione Peroxidase/blood MH - Lipid Peroxidation/drug effects MH - Liver/enzymology MH - Rats MH - Superoxide Dismutase/metabolism EDAT- 2000/06/24 11:00 MHDA- 2000/07/25 11:00 CRDT- 2000/06/24 11:00 PHST- 2000/06/24 11:00 [pubmed] PHST- 2000/07/25 11:00 [medline] PHST- 2000/06/24 11:00 [entrez] PST - ppublish SO - Indian J Exp Biol. 1999 Dec;37(12):1187-91.