PMID- 10867144
OWN - NLM
STAT- MEDLINE
DCOM- 20000719
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 119
IP  - 2
DP  - 2000 Jun
TI  - Balanced translocation (3;7)(p25;q34): another mechanism of tumorigenesis in 
      follicular thyroid carcinoma?
PG  - 109-12
AB  - Alterations of 3p are the most frequently observed changes in follicular thyroid 
      carcinomas. Loss of 3p25-pter has been speculated to be a critical event in the 
      malignant transformation of a subset of thyroid follicular neoplasms. The present 
      report describes a minimally invasive follicular thyroid carcinoma (FTC) with a 
      balanced t(3;7)(p25;q34) and dic(15;22)(p11;p11) as the only abnormalities. The 
      alterations were present in all metaphases analyzed and were demonstrated by 
      G-banding, spectral karyotyping (SKY), and fluorescence in situ hybridization 
      (FISH). This study represents the second case of FTC where 3p25 is involved in a 
      balanced translocation. The findings support the existence of a gene locus in 
      this region which is involved in the tumorigenesis of thyroid carcinoma.
FAU - Lui, W O
AU  - Lui WO
AD  - Department of Molecular Medicine, Endocrine Tumor Unit, Karolinska Hospital, 
      Stockholm, Sweden.
FAU - Kytola, S
AU  - Kytola S
FAU - Anfalk, L
AU  - Anfalk L
FAU - Larsson, C
AU  - Larsson C
FAU - Farnebo, L O
AU  - Farnebo LO
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adenocarcinoma, Follicular/etiology/*genetics
MH  - Aged
MH  - Animals
MH  - Chromosomes, Human, Pair 3/genetics/*ultrastructure
MH  - Chromosomes, Human, Pair 7/genetics/*ultrastructure
MH  - Dogs
MH  - Humans
MH  - Karyotyping
MH  - Male
MH  - Thyroid Neoplasms/etiology/*genetics
MH  - *Translocation, Genetic
RF  - 15
EDAT- 2000/06/27 00:00
MHDA- 2000/06/27 00:01
CRDT- 2000/06/27 00:00
PHST- 2000/06/27 00:00 [pubmed]
PHST- 2000/06/27 00:01 [medline]
PHST- 2000/06/27 00:00 [entrez]
AID - S0165-4608(99)00224-1 [pii]
AID - 10.1016/s0165-4608(99)00224-1 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Jun;119(2):109-12. doi: 
      10.1016/s0165-4608(99)00224-1.