PMID- 10867550
OWN - NLM
STAT- MEDLINE
DCOM- 20000829
LR  - 20171101
IS  - 0302-282X (Print)
IS  - 0302-282X (Linking)
VI  - 42
IP  - 1
DP  - 2000
TI  - (+/-)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin 
      neurotoxicity: studies in animals.
PG  - 5-10
AB  - The popular recreational drug, (+/-)3, 4-methylenedioxymethamphetamine (MDMA; 
      'Ecstasy') is a potent and selective brain serotonin (5-HT) neurotoxin in 
      animals. MDMA-induced 5-HT neurotoxicity can be demonstrated using a variety of 
      neurochemical, neuroanatomical and, more recently, functional measures of 5-HT 
      neurons. Although the neurotoxic effects of MDMA in animals are widely accepted, 
      the relevance of the animal data to human MDMA users has been questioned, largely 
      because dosages of drugs used in animals are perceived as being much higher than 
      those used by humans. In the present paper, we review the extensive body of data 
      demonstrating that MDMA produced toxic effects on brain 5-HT neurons in animals 
      and present new data indicating that levels of the type 2 vesicular monoamine 
      transporter are reduced in MDMA-treated animals, providing further indication of 
      MDMA's 5-HT neurotoxic potential. Further, we demonstrate, using principles of 
      interspecies scaling, that dosages of MDMA known to be neurotoxic in animals fall 
      squarely in the range of dosages used typically by recreational MDMA users.
CI  - Copyright 2000 S. Karger AG, Basel
FAU - Ricaurte, G A
AU  - Ricaurte GA
AD  - Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21224, 
      USA.
FAU - Yuan, J
AU  - Yuan J
FAU - McCann, U D
AU  - McCann UD
LA  - eng
GR  - DA00206/DA/NIDA NIH HHS/United States
GR  - DA05707/DA/NIDA NIH HHS/United States
GR  - DA06275/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Serotonin Agents)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neurons/drug effects/metabolism/pathology
MH  - Neurotoxicity Syndromes/*pathology
MH  - Serotonin Agents/*toxicity
RF  - 50
EDAT- 2000/06/27 11:00
MHDA- 2000/09/02 11:01
CRDT- 2000/06/27 11:00
PHST- 2000/06/27 11:00 [pubmed]
PHST- 2000/09/02 11:01 [medline]
PHST- 2000/06/27 11:00 [entrez]
AID - 26664 [pii]
AID - 10.1159/000026664 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2000;42(1):5-10. doi: 10.1159/000026664.