PMID- 10871792
OWN - NLM
STAT- MEDLINE
DCOM- 20000727
LR  - 20051116
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 6 Suppl 2
DP  - 2000 May
TI  - Extended observations on the association of HHV-6 and multiple sclerosis.
PG  - S85-7
AB  - Throughout the years, a long list of viruses has been associated with multiple 
      sclerosis (MS), however no virus to date has been definitively identified as the 
      etiologic agent of this disease. Recently, human herpesvirus 6 (HHV-6), a newly 
      described herpesvirus, has been suggested to play a role in MS based on: 
      immunohistochemical demonstration of HHV-6 in MS plaques, increased antibodies 
      response to HHV-6 in sera and CSF of MS patients, and the demonstration of HHV-6 
      DNA in the serum of MS patients but not in normal individuals. To extend these 
      observations we have focused our research in multiple directions. We have 
      increased the number of MS patients tested for HHV-6 serum DNA providing 
      confirmation of our previous study. Additionally we have investigated a possible 
      correlation between HHV-6 viremia and clinical activity. Finally to provide 
      insight into the pathogenesis of this disease, we have begun to characterize the 
      cellular immune response of MS patients to HHV-6. Collectively these studies will 
      help to define the role that HHV-6 may play in the pathogenesis of MS.
FAU - Berti, R
AU  - Berti R
AD  - Viral Immunology Section, Neuroimmunology Branch, National Institutes of Health, 
      Bethesda, Maryland, MD 20892, USA.
FAU - Soldan, S S
AU  - Soldan SS
FAU - Akhyani, N
AU  - Akhyani N
FAU - McFarland, H F
AU  - McFarland HF
FAU - Jacobson, S
AU  - Jacobson S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
SB  - IM
MH  - Herpesviridae Infections/*immunology
MH  - Herpesvirus 6, Human/*immunology
MH  - Humans
MH  - Multiple Sclerosis/*immunology/*virology
RF  - 17
EDAT- 2000/06/29 11:00
MHDA- 2000/08/01 11:00
CRDT- 2000/06/29 11:00
PHST- 2000/06/29 11:00 [pubmed]
PHST- 2000/08/01 11:00 [medline]
PHST- 2000/06/29 11:00 [entrez]
PST - ppublish
SO  - J Neurovirol. 2000 May;6 Suppl 2:S85-7.