PMID- 10871793
OWN - NLM
STAT- MEDLINE
DCOM- 20000727
LR  - 20061115
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 6 Suppl 2
DP  - 2000 May
TI  - Novel human herpesviruses and multiple sclerosis.
PG  - S88-91
AB  - It has been suggested that human herpesvirus 6 (HHV-6) might be involved in the 
      pathogenesis of multiple sclerosis (MS). However, studies of the association 
      between HHV-6 and MS are hindered by the difficulty in discriminating between 
      latent and active infection. We undertook a study to determine whether HHV-6 
      establish a systemic active infection in the course of MS, and to investigate 
      possible roles of HHV-7, a herpesvirus closely related to HHV-6. To discriminate 
      between latent and active infection, we analysed viral transcription. The results 
      indicate that both viruses are prevalent in PBMCs of MS patients as in healthy 
      controls, and that viral sequences are maintained in a non-transcriptional state. 
      These observations indicate that further studies should define the state of viral 
      persistence in the central nervous system.
FAU - Rotola, A
AU  - Rotola A
AD  - Department of Experimental and Diagnostic Medicine, Section of Microbiology, 
      University of Ferrara, Italy.
FAU - Caselli, E
AU  - Caselli E
FAU - Cassai, E
AU  - Cassai E
FAU - Tola, M R
AU  - Tola MR
FAU - Granieri, E
AU  - Granieri E
FAU - Luca, D D
AU  - Luca DD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (DNA, Viral)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - DNA, Viral/analysis
MH  - Gene Expression Regulation, Viral
MH  - Herpesviridae Infections/*immunology
MH  - Herpesvirus 6, Human/*genetics/immunology
MH  - Herpesvirus 7, Human/*genetics/immunology
MH  - Humans
MH  - Leukocytes, Mononuclear/immunology/virology
MH  - Multiple Sclerosis, Relapsing-Remitting/immunology/*virology
MH  - Polymerase Chain Reaction
MH  - RNA, Viral/analysis
MH  - Transcription, Genetic
EDAT- 2000/06/29 11:00
MHDA- 2000/08/01 11:00
CRDT- 2000/06/29 11:00
PHST- 2000/06/29 11:00 [pubmed]
PHST- 2000/08/01 11:00 [medline]
PHST- 2000/06/29 11:00 [entrez]
PST - ppublish
SO  - J Neurovirol. 2000 May;6 Suppl 2:S88-91.