PMID- 10872117
OWN - NLM
STAT- MEDLINE
DCOM- 20000801
LR  - 20191025
IS  - 0017-6192 (Print)
IS  - 0017-6192 (Linking)
VI  - 48
IP  - 5
DP  - 2000 May
TI  - [Detection of numerical chromosome aberrations in leukoplakia and squamous 
      epithelial carcinomas of the head-neck area using fluorescence in situ 
      hybridization].
PG  - 367-71
AB  - The tumorigenesis of head and neck squamous cell carcinoma (HNSCC) has been 
      proposed to represent a multistep process characterized by an accumulation of 
      genetic alterations. To study numerical chromosomal aberrations and chromosomal 
      imbalances, biopsies of 11 malignant tumours and biopsies of 16 oral premalignant 
      lesions (leukoplakias) were analyzed by fluorescence in situ hybridization (FISH) 
      using centromeric probes for chromosomes, 1, 7, 9, 10 and 17. The comparison of 
      the alterations observed in simple leukoplakias (group 1, n = 8), dysplastic 
      leukoplakias (group 2, n = 8) and malignant tumours (group 3, n = 11) by the 
      Cochran-Armitage Trend Test revealed an increasing number of numerical 
      chromosomal abberations. This difference was statistically highly significant (p 
      < 0.001). The data open up the possibility that FISH analysis might help to 
      better characterize the progression of premalignant oral leukoplakias.
FAU - Lenz, C
AU  - Lenz C
AD  - Universitats-HNO-Klinik Heidelberg.
FAU - Dietz, A
AU  - Dietz A
FAU - Pfuhl, A
AU  - Pfuhl A
FAU - Finckh, M
AU  - Finckh M
FAU - Conradt, C
AU  - Conradt C
FAU - Weidauer, H
AU  - Weidauer H
FAU - Bosch, F X
AU  - Bosch FX
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Nachweis von numerischen Chromosomenaberrationen in Leukoplakien und 
      Plattenepithelkarzinomen des Kopf-Hals-Bereichs mittels der 
      Fluoreszenz-in-situ-Hybridisierung.
PL  - Germany
TA  - HNO
JT  - HNO
JID - 2985099R
SB  - IM
MH  - Biopsy
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Cell Transformation, Neoplastic/genetics/pathology
MH  - Chromosome Aberrations/*genetics
MH  - Disease Progression
MH  - Humans
MH  - Hypopharyngeal Neoplasms/*genetics/pathology
MH  - *In Situ Hybridization, Fluorescence
MH  - Leukoplakia, Oral/*genetics/pathology
MH  - Mouth Mucosa/pathology
MH  - Neoplasm Staging
MH  - Oropharyngeal Neoplasms/*genetics/pathology
MH  - Predictive Value of Tests
EDAT- 2000/06/29 11:00
MHDA- 2000/08/06 11:00
CRDT- 2000/06/29 11:00
PHST- 2000/06/29 11:00 [pubmed]
PHST- 2000/08/06 11:00 [medline]
PHST- 2000/06/29 11:00 [entrez]
AID - 10.1007/s001060050582 [doi]
PST - ppublish
SO  - HNO. 2000 May;48(5):367-71. doi: 10.1007/s001060050582.