PMID- 10872274
OWN - NLM
STAT- MEDLINE
DCOM- 20000727
LR  - 20091109
IS  - 0350-199X (Linking)
VI  - 54
IP  - 1
DP  - 2000
TI  - [Molecular mechanisms in apoptosis].
PG  - 33-40
AB  - Apoptosis is evolutionary conserved form of cell suicide. Tumor necrosis 
      factor-alpha (TNF-alpha) or Fas Ligand activated apoptosis by binding of the 
      plasma membrane receptor. The activation of TNF Receptor 1 or Fas-Ligand Receptor 
      lead to activate of caspase 8. The activation of the caspase-8 lead to activate 
      the cell-death machinery cascade. The inhibitor of cell death machinery is Bcl-2 
      also fails to prevent Bax-induced cytochrome c release, activation of caspase-3, 
      membrane blebbing, nuclear fragmentation, and cell death. Bcl-2 is important cell 
      live-death regulator. Cleavage of specific protein subsets is a key event in the 
      execution of apoptosis. Protein degradation may serve for the structural 
      alterations in the process of cell self-destruction, but it may also function as 
      a switch in the decisions between apoptosis and necrosis or apoptosis and cell 
      proliferation.
FAU - Habibovic, S
AU  - Habibovic S
AD  - Krankenhaus Sachsenhausen, Frauenklinik, Frankfurt, Germany.
FAU - Hrgovic, Z
AU  - Hrgovic Z
FAU - Bukvic, I
AU  - Bukvic I
FAU - Hrgovic, I
AU  - Hrgovic I
LA  - hrv
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Molekularni mehanizmi kod apoptoze.
PL  - Bosnia and Herzegovina
TA  - Med Arh
JT  - Medicinski arhiv
JID - 0400722
RN  - 0 (Cytochrome c Group)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Caspases/physiology
MH  - Cytochrome c Group/physiology
MH  - Humans
MH  - Proto-Oncogene Proteins c-bcl-2/physiology
MH  - Tumor Necrosis Factor-alpha/physiology
RF  - 83
EDAT- 2000/06/29 11:00
MHDA- 2000/08/01 11:00
CRDT- 2000/06/29 11:00
PHST- 2000/06/29 11:00 [pubmed]
PHST- 2000/08/01 11:00 [medline]
PHST- 2000/06/29 11:00 [entrez]
PST - ppublish
SO  - Med Arh. 2000;54(1):33-40.