PMID- 10872675
OWN - NLM
STAT- MEDLINE
DCOM- 20000706
LR  - 20071115
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 31
IP  - 6
DP  - 2000 Jun
TI  - Chromosomal translocations are common in natural killer-cell lymphoma/leukemia as 
      shown by spectral karyotyping.
PG  - 771-4
AB  - Natural killer (NK)-cell lymphoma/leukemia is a group of rare but highly 
      aggressive neoplasms. The associated genetic aberrations, as defined by 
      conventional cytogenetics, include 6q deletion and chromosome X copy gain, while 
      translocations have been suggested to be uncommon. In this study, three cases of 
      NK cell lymphoma/ leukemia were investigated by spectral karyotyping (SKY). SKY 
      permitted reinterpretation of the chromosomal alterations defined by G-banding 
      and identified several cryptic translocations. In agreement with G-band, 6q 
      deletion was detected in all 3 cases. Structural rearrangement involving 
      chromosome X was observed in 2 cases, and fluorescence in situ hybridization 
      (FISH) analysis indicated that both translocations involved Xp21-pter. Chromosome 
      8 translocation was also identified in 2 cases and shared a common breakpoint, 
      8p23. The present study shows the value of SKY in providing additional 
      information on karyotypic abnormalities. The novel findings of recurring 
      Xp21-pter rearrangements and 8p23 translocation should provide basis for further 
      investigations into the tumorigenesis of NK cell lymphoma/leukemia.
FAU - Wong, N
AU  - Wong N
AD  - Department of Clinical Oncology at the Sir Y.K. Pao Centre for Cancer, The 
      Chinese University of Hong Kong, Shatin.
FAU - Wong, K F
AU  - Wong KF
FAU - Chan, J K
AU  - Chan JK
FAU - Johnson, P J
AU  - Johnson PJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
SB  - IM
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 6
MH  - Chromosomes, Human, Pair 8
MH  - Gene Deletion
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Karyotyping
MH  - *Killer Cells, Natural
MH  - Leukemia, Lymphoid/*genetics
MH  - Lymphoma/*genetics
MH  - *Translocation, Genetic
MH  - X Chromosome
EDAT- 2000/06/29 11:00
MHDA- 2000/07/08 11:00
CRDT- 2000/06/29 11:00
PHST- 2000/06/29 11:00 [pubmed]
PHST- 2000/07/08 11:00 [medline]
PHST- 2000/06/29 11:00 [entrez]
AID - S0046-8177(00)80124-0 [pii]
AID - 10.1053/hupa.2000.7625 [doi]
PST - ppublish
SO  - Hum Pathol. 2000 Jun;31(6):771-4. doi: 10.1053/hupa.2000.7625.