PMID- 10873932
OWN - NLM
STAT- MEDLINE
DCOM- 20000719
LR  - 20100323
IS  - 0002-953X (Print)
IS  - 0002-953X (Linking)
VI  - 157
IP  - 7
DP  - 2000 Jul
TI  - Human leukocyte antigen and season of birth in Japanese patients with 
      schizophrenia.
PG  - 1173-5
AB  - OBJECTIVE: Five Japanese studies, to the authors' knowledge, without exception, 
      have consistently shown an increased frequency of human leukocyte antigen 
      (HLA)-DR1 in patients with schizophrenia. This suggests an association between 
      HLA-DR1 and schizophrenia in the Japanese population. The mechanism of the 
      association is unknown; however, prenatal infections may be involved. The present 
      study explored factors, including winter birth, that might correlate with this 
      mechanism. Age at onset and gender were also studied. METHOD: Factors were 
      compared between Japanese patients with schizophrenia with and in those without 
      HLA-DR1 (N=60 and N=307, respectively). RESULTS: A significantly higher incidence 
      of births in February and March was observed in patients with (31.7%) than those 
      without (15. 6%) HLA-DR1. No association was found between the presence of 
      HLA-DR1 and other variables. CONCLUSIONS: Although this result is preliminary, it 
      may suggest an interaction between HLA and winter birth in the development of 
      schizophrenia in the Japanese population.
FAU - Narita, K
AU  - Narita K
AD  - Department of Psychiatry, Mizonokuchi Hospital, Teikyo University, Kawasaki, 
      Japan.
FAU - Sasaki, T
AU  - Sasaki T
FAU - Akaho, R
AU  - Akaho R
FAU - Okazaki, Y
AU  - Okazaki Y
FAU - Kusumi, I
AU  - Kusumi I
FAU - Kato, T
AU  - Kato T
FAU - Hashimoto, O
AU  - Hashimoto O
FAU - Fukuda, R
AU  - Fukuda R
FAU - Koyama, T
AU  - Koyama T
FAU - Matsuo, K
AU  - Matsuo K
FAU - Okabe, Y
AU  - Okabe Y
FAU - Nanko, S
AU  - Nanko S
FAU - Hohjoh, H
AU  - Hohjoh H
FAU - Tokunaga, K
AU  - Tokunaga K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Psychiatry
JT  - The American journal of psychiatry
JID - 0370512
RN  - 0 (HLA-DR1 Antigen)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Female
MH  - HLA-DR1 Antigen/*analysis/genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Risk Factors
MH  - Schizophrenia/*epidemiology/genetics
MH  - *Seasons
MH  - Sex Factors
EDAT- 2000/06/30 11:00
MHDA- 2000/07/25 11:00
CRDT- 2000/06/30 11:00
PHST- 2000/06/30 11:00 [pubmed]
PHST- 2000/07/25 11:00 [medline]
PHST- 2000/06/30 11:00 [entrez]
AID - 10.1176/appi.ajp.157.7.1173 [doi]
PST - ppublish
SO  - Am J Psychiatry. 2000 Jul;157(7):1173-5. doi: 10.1176/appi.ajp.157.7.1173.