PMID- 10877223
OWN - NLM
STAT- MEDLINE
DCOM- 20000712
LR  - 20190721
IS  - 0163-2116 (Print)
IS  - 0163-2116 (Linking)
VI  - 45
IP  - 6
DP  - 2000 Jun
TI  - HLA-A33/B44/DR6 is highly related to intrahepatic cholestasis induced by 
      tiopronin.
PG  - 1103-8
AB  - In order to elucidate the immunogenetic predisposition of tiopronin 
      (mercaptopropionylglycine)-induced intrahepatic cholestasis, human leukocyte 
      antigen (HLA) was analyzed in patients with tiopronin-induced liver injury. 
      HLA-A, -B, -C, and -DR loci of 14 patients (10 males and 4 females) with 
      tiopronin-induced liver injury were compared with those of control subjects. The 
      mean duration of tiopronin administration was 26 days and that of jaundice was 
      4.5 months. The elevation of biliary enzymes lasted from 2 months to up to 10 
      years. Most of the cases manifested intrahepatic cholestasis on liver biopsy. 
      Lymphocyte transformation test with tiopronin was positive in 6 of 8 (75%) tested 
      cases. Thirteen patients (92.9%) had HLA-A33, 10 (71.4%) had B44, and 9 (64.3%) 
      patients had DR6. These are statistically higher in the patients with 
      tiopronin-induced cholestasis than in the general population. Ten of those with 
      tiopronin-induced liver dysfunction (71.4%) had A33/B44 and 8 (57.1%) had 
      A33/B44/DR6 in their haplotype. In conclusion, long-lasting tiopronin-induced 
      intrahepatic-cholestasis is highly linked to specific HLA-A33, -B44 and -DR6.
FAU - Kurosaki, M
AU  - Kurosaki M
AD  - First Department of Internal Medicine, Gunma University, School of Medicine, 
      Maebashi, Japan.
FAU - Takagi, H
AU  - Takagi H
FAU - Mori, M
AU  - Mori M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*33 antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B44 Antigen)
RN  - 0 (HLA-DR6 Antigen)
RN  - C5W04GO61S (Tiopronin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cholestasis, Intrahepatic/*chemically induced/*immunology/pathology
MH  - Female
MH  - HLA-A Antigens/*analysis
MH  - HLA-B Antigens/*analysis
MH  - HLA-B44 Antigen
MH  - HLA-DR6 Antigen/*analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Tiopronin/*adverse effects
EDAT- 2000/07/06 11:00
MHDA- 2000/07/15 11:00
CRDT- 2000/07/06 11:00
PHST- 2000/07/06 11:00 [pubmed]
PHST- 2000/07/15 11:00 [medline]
PHST- 2000/07/06 11:00 [entrez]
AID - 10.1023/a:1005585515826 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2000 Jun;45(6):1103-8. doi: 10.1023/a:1005585515826.