PMID- 10877914
OWN - NLM
STAT- MEDLINE
DCOM- 20000816
LR  - 20220310
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 164
IP  - 1
DP  - 2000 Jul
TI  - Long-term environmental enrichment leads to regional increases in neurotrophin 
      levels in rat brain.
PG  - 45-52
AB  - A number of studies have demonstrated that both morphological and biochemical 
      indices in the brain undergo alterations in response to environmental influences. 
      In previous work we have shown that rats raised in an enriched environmental 
      condition (EC) perform better on a spatial memory task than rats raised in 
      isolated conditions (IC). We have also found that EC rats have a higher density 
      of immunoreactivity than IC rats for both low and high affinity nerve growth 
      factor (NGF) receptors in the basal forebrain. In order to determine if these 
      alterations were coupled with altered levels of neurotrophins in other brain 
      regions as well, we measured neurotrophin levels in rats that were raised in EC 
      or IC conditions. Rats were placed in the different environments at 2 months of 
      age and 12 months later brain regions were dissected and analyzed for NGF, 
      brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) levels using 
      Promega ELISA kits. We found that NGF and BDNF levels were increased in the 
      cerebral cortex, hippocampal formation, basal forebrain, and hindbrain in EC 
      animals compared to age-matched IC animals. NT-3 was found to be increased in the 
      basal forebrain and cerebral cortex of EC animals as well. These findings 
      demonstrate significant alterations in NGF, BDNF, and NT-3 protein levels in 
      several brain regions as a result of an enriched versus an isolated environment 
      and thus provide a possible biochemical basis for behavioral and morphological 
      alterations that have been found to occur with a shifting environmental stimulus.
CI  - Copyright 2000 Academic Press.
FAU - Ickes, B R
AU  - Ickes BR
AD  - Department of Basic Science, University of Colorado HSC, Denver 80262, USA.
FAU - Pham, T M
AU  - Pham TM
FAU - Sanders, L A
AU  - Sanders LA
FAU - Albeck, D S
AU  - Albeck DS
FAU - Mohammed, A H
AU  - Mohammed AH
FAU - Granholm, A C
AU  - Granholm AC
LA  - eng
GR  - AG15239/AG/NIA NIH HHS/United States
GR  - AG12122/AG/NIA NIH HHS/United States
GR  - AG04418/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cerebral Cortex/metabolism
MH  - Environment Design
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/metabolism
MH  - Housing, Animal
MH  - Male
MH  - Nerve Growth Factor/metabolism
MH  - Nerve Growth Factors/*metabolism
MH  - Neurotrophin 3/metabolism
MH  - Play and Playthings
MH  - Prosencephalon/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rhombencephalon/metabolism
MH  - *Social Environment
MH  - *Social Facilitation
MH  - Social Isolation
EDAT- 2000/07/06 11:00
MHDA- 2000/08/19 11:00
CRDT- 2000/07/06 11:00
PHST- 2000/07/06 11:00 [pubmed]
PHST- 2000/08/19 11:00 [medline]
PHST- 2000/07/06 11:00 [entrez]
AID - S0014-4886(00)97415-6 [pii]
AID - 10.1006/exnr.2000.7415 [doi]
PST - ppublish
SO  - Exp Neurol. 2000 Jul;164(1):45-52. doi: 10.1006/exnr.2000.7415.