PMID- 10879998
OWN - NLM
STAT- MEDLINE
DCOM- 20001019
LR  - 20130731
IS  - 1018-9068 (Print)
IS  - 1018-9068 (Linking)
VI  - 10
IP  - 2
DP  - 2000 Mar-Apr
TI  - Tumor necrosis factor-alpha binding by peripheral blood lymphocytes and 
      polymorphonuclear neutrophils in patients with multiple sclerosis.
PG  - 98-101
AB  - Tumor necrosis factor-alpha (TNF-alpha) in multiple sclerosis (MS) is responsible 
      for peripheral blood leukocyte priming. The aim of this study was to evaluate 
      fluorescein isothiocyanate (FITC)-labelled TNF binding ability by peripheral 
      blood lymphocytes and polymorphonuclear neutrophils (PMNs) of MS patients, 
      measured using flow cytometry (FACScan). Three groups of MS patients (total 34) 
      were examined. Higher serum levels of TNF soluble receptors sp55 and sp75 were 
      found in the MS patients during MS acute exacerbation (n = 10) and in chronic 
      progressive forms (n = 11) as compared to MS remission (n = 13) and other 
      neurological diseases (n = 14). Peripheral blood lymphocytes and PMNs of patients 
      with acute exacerbation of MS bound TNF-FITC more effectively (p <0.01) as 
      compared with the chronic progressive forms of MS, MS remission and other 
      neurological diseases. The obtained results suggest a greater enhancement of TNF 
      activity during MS acute exacerbation.
FAU - Ziaber, J
AU  - Ziaber J
AD  - Department of Neurology, Military Medical Academy of Lodz, Poland.
FAU - Pasnik, J
AU  - Pasnik J
FAU - Baj, Z
AU  - Baj Z
FAU - Pokoca, L
AU  - Pokoca L
FAU - Chmielewski, H
AU  - Chmielewski H
FAU - Tchorzewski, H
AU  - Tchorzewski H
LA  - eng
PT  - Journal Article
PL  - Spain
TA  - J Investig Allergol Clin Immunol
JT  - Journal of investigational allergology & clinical immunology
JID - 9107858
RN  - 0 (Antigens, CD)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Antigens, CD/*blood
MH  - Flow Cytometry
MH  - Humans
MH  - Leukocytes, Mononuclear/*metabolism
MH  - Middle Aged
MH  - Multiple Sclerosis/*immunology
MH  - Neutrophils/*metabolism
MH  - Receptors, Tumor Necrosis Factor/*blood
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Receptors, Tumor Necrosis Factor, Type II
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2000/07/06 11:00
MHDA- 2000/10/21 11:01
CRDT- 2000/07/06 11:00
PHST- 2000/07/06 11:00 [pubmed]
PHST- 2000/10/21 11:01 [medline]
PHST- 2000/07/06 11:00 [entrez]
PST - ppublish
SO  - J Investig Allergol Clin Immunol. 2000 Mar-Apr;10(2):98-101.