PMID- 10880386
OWN - NLM
STAT- MEDLINE
DCOM- 20000808
LR  - 20231213
IS  - 0002-9440 (Print)
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 157
IP  - 1
DP  - 2000 Jul
TI  - Human decidua contains potent immunostimulatory CD83(+) dendritic cells.
PG  - 159-69
AB  - Dendritic cells (DCs) are sentinel cells of the immune system important in 
      initiating antigen-specific T-cell responses to microbial and transplantation 
      antigens. DCs are particularly found in surface tissues such as skin and mucosa, 
      where the organism is threatened by infectious agents. The human decidua, despite 
      its proposed immunosuppressive function, hosts a variety of immunocompetent CD45 
      cells such as natural killer cells, macrophages, and T cells. Here we describe 
      the detection, isolation, and characterization of CD45(+), CD40(+), HLA-DR(++), 
      and CD83(+) cells from human early pregnancy decidua with typical DC morphology. 
      CD83(+) as well as CD1a(+) cells were found in close vicinity to endometrial 
      glands, with preference to the basal layer of the decidua. In vitro, decidual 
      CD83(+) cells could be enriched to approximately 30%, with the remainder of cells 
      encompassing DC-bound CD3(+) T cells. Stimulation of allogeneic T cells in a 
      mixed leukocyte reaction by the decidual cell fraction enriched for CD83(+) 
      cells, was similar to that obtained with blood monocyte-derived DCs, 
      demonstrating the potent immunostimulatory capacity of these cells. Decidual DCs 
      with morphological, phenotypic, and functional characteristics of 
      immunostimulatory DCs might be important mediators in the regulation of 
      immunological balance between maternal and fetal tissue, leading to successful 
      pregnancy.
FAU - Kammerer, U
AU  - Kammerer U
AD  - Department of Obstetrics and Gynecology, University of Wurzburg, Germany. 
      frak057@mail.uni-wuerzberg.de
FAU - Schoppet, M
AU  - Schoppet M
FAU - McLellan, A D
AU  - McLellan AD
FAU - Kapp, M
AU  - Kapp M
FAU - Huppertz, H I
AU  - Huppertz HI
FAU - Kampgen, E
AU  - Kampgen E
FAU - Dietl, J
AU  - Dietl J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Antigens, CD
MH  - Antigens, CD1/analysis
MH  - Decidua/*chemistry/cytology
MH  - Dendritic Cells/*chemistry/cytology
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Immunoglobulins/*analysis
MH  - Immunohistochemistry
MH  - Membrane Glycoproteins/*analysis
MH  - Pregnancy
MH  - CD83 Antigen
PMC - PMC1850207
EDAT- 2000/07/06 11:00
MHDA- 2000/08/12 11:00
PMCR- 2001/01/01
CRDT- 2000/07/06 11:00
PHST- 2000/07/06 11:00 [pubmed]
PHST- 2000/08/12 11:00 [medline]
PHST- 2000/07/06 11:00 [entrez]
PHST- 2001/01/01 00:00 [pmc-release]
AID - S0002-9440(10)64527-0 [pii]
AID - 2247 [pii]
AID - 10.1016/S0002-9440(10)64527-0 [doi]
PST - ppublish
SO  - Am J Pathol. 2000 Jul;157(1):159-69. doi: 10.1016/S0002-9440(10)64527-0.