PMID- 10880699
OWN - NLM
STAT- MEDLINE
DCOM- 20000828
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 66
IP  - 2
DP  - 2000 Jun
TI  - Opiate withdrawal in the fetal rat: a behavioral profile.
PG  - 419-24
AB  - Offspring of women exposed to opiate drugs such as heroin and methadone during 
      pregnancy have a high incidence of morbidity and mortality. Infants also show 
      opiate withdrawal. In this study, we examined the behavioral effects of 
      precipitated withdrawal in morphine-dependent fetal rats at gestational day (GD) 
      20. The dam was implanted on GD 14 with a pellet containing 75.0 mg of morphine. 
      On GD 20, the dam underwent chemoyelotomy at L1/L2. The uterine horns were 
      externalized and four subject fetuses were selected for behavioral observation, 
      two from each uterine horn. The fetus was then injected subcutaneously with 
      either saline or naltrexone (1.0 mg/kg) and the behaviors of the fetus recorded 
      every 15 sec for 20 min. The results show that naltrexone injected fetuses that 
      had been chronically exposed to morphine demonstrated increased limb and mouth 
      movements, face wiping, and body curls, and spent less time quiet as compared 
      with control fetuses. These results indicate that a morphine withdrawal-like 
      syndrome occurs in the fetal rat.
FAU - Jones, K L
AU  - Jones KL
AD  - Biopsychology Doctoral Program, Department of Psychology, Hunter College, City 
      University of New York, 695 Park Avenue, New York, NY 10021, USA.
FAU - Barr, G A
AU  - Barr GA
LA  - eng
GR  - F31 DA-05632/DA/NIDA NIH HHS/United States
GR  - K02 DA00325/DA/NIDA NIH HHS/United States
GR  - R01 DA06600/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Narcotic Antagonists)
RN  - 5S6W795CQM (Naltrexone)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects/physiology
MH  - Disease Models, Animal
MH  - Female
MH  - Fetus/*drug effects/*physiopathology
MH  - Humans
MH  - Maternal-Fetal Exchange
MH  - Morphine/*toxicity
MH  - Motor Activity/drug effects/physiology
MH  - Naltrexone/pharmacology
MH  - Narcotic Antagonists/pharmacology
MH  - Pregnancy
MH  - Rats
MH  - Substance Withdrawal Syndrome/*psychology
EDAT- 2000/07/06 11:00
MHDA- 2000/09/02 11:01
CRDT- 2000/07/06 11:00
PHST- 2000/07/06 11:00 [pubmed]
PHST- 2000/09/02 11:01 [medline]
PHST- 2000/07/06 11:00 [entrez]
AID - S0091-3057(00)00209-4 [pii]
AID - 10.1016/s0091-3057(00)00209-4 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2000 Jun;66(2):419-24. doi: 
      10.1016/s0091-3057(00)00209-4.