PMID- 10882019
OWN - NLM
STAT- MEDLINE
DCOM- 20001103
LR  - 20190831
IS  - 0968-0896 (Print)
IS  - 0968-0896 (Linking)
VI  - 8
IP  - 5
DP  - 2000 May
TI  - Conformationally restricted analogues designed for selective inhibition of GAR 
      Tfase versus thymidylate synthase or dihydrofolate reductase.
PG  - 1075-86
AB  - The synthesis and evaluation of a series of conformationally restricted analogues 
      of 10-formyl-tetrahydrofolate as potential inhibitors of glycinamide 
      ribonucleotide transformylase (GAR Tfase) or aminoimidazole carboxamide 
      transformylase (AICAR Tfase) are reported.
FAU - Boger, D L
AU  - Boger DL
AD  - Department of Chemistry and The Skaggs Institute for Chemical Biology, The 
      Scripps Research Institute, La Jolla, CA 92037, USA. boger@scripps.edu
FAU - Labroli, M A
AU  - Labroli MA
FAU - Marsilje, T H
AU  - Marsilje TH
FAU - Jin, Q
AU  - Jin Q
FAU - Hedrick, M P
AU  - Hedrick MP
FAU - Baker, S J
AU  - Baker SJ
FAU - Shim, J H
AU  - Shim JH
FAU - Benkovic, S J
AU  - Benkovic SJ
LA  - eng
GR  - CA 63536/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Bioorg Med Chem
JT  - Bioorganic & medicinal chemistry
JID - 9413298
RN  - 0 (Folic Acid Antagonists)
RN  - EC 1.5.1.3 (Tetrahydrofolate Dehydrogenase)
RN  - EC 2.1.1.45 (Thymidylate Synthase)
RN  - EC 2.1.2.- (Hydroxymethyl and Formyl Transferases)
RN  - EC 2.1.2.2 (Phosphoribosylglycinamide Formyltransferase)
SB  - IM
MH  - Cell Line
MH  - Cell Survival
MH  - Folic Acid Antagonists/*chemistry/pharmacology
MH  - Humans
MH  - Hydroxymethyl and Formyl Transferases/*antagonists & inhibitors
MH  - Magnetic Resonance Spectroscopy
MH  - Mass Spectrometry
MH  - Molecular Structure
MH  - Phosphoribosylglycinamide Formyltransferase
MH  - Tetrahydrofolate Dehydrogenase/*drug effects
MH  - Thymidylate Synthase/*antagonists & inhibitors
EDAT- 2000/07/06 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/07/06 11:00
PHST- 2000/07/06 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/07/06 11:00 [entrez]
AID - S0968-0896(00)00051-1 [pii]
AID - 10.1016/s0968-0896(00)00051-1 [doi]
PST - ppublish
SO  - Bioorg Med Chem. 2000 May;8(5):1075-86. doi: 10.1016/s0968-0896(00)00051-1.