PMID- 10882847
OWN - NLM
STAT- MEDLINE
DCOM- 20000906
LR  - 20220408
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 23
IP  - 2
DP  - 2000 Aug
TI  - Long-term repetitive transcranial magnetic stimulation increases the expression 
      of brain-derived neurotrophic factor and cholecystokinin mRNA, but not 
      neuropeptide tyrosine mRNA in specific areas of rat brain.
PG  - 205-15
AB  - Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a 
      therapeutic tool in various neurological and psychiatric disorders, and we 
      recently found that it has a neuroprotective effect both in vitro and in vivo. 
      However, the neurochemical mechanisms underlying the therapeutic effects are 
      still unknown. We investigated the effects of long-term rTMS on the expression of 
      brain-derived neurotrophic factor (BDNF), cholecystokinin (CCK), and neuropeptide 
      tyrosine (NPY) mRNA in rat brain. In situ hybridization revealed a significant 
      increase in BDNF mRNA in the hippocampal areas CA3 and CA3c, the granule cell 
      layer, as well as in the parietal and the piriform cortex after rTMS. BDNF-like 
      immunoreactivity was markedly increased in the same areas. A significant increase 
      in CCK mRNA was observed in all brain regions examined. NPY mRNA expression, in 
      contrast, was not altered. The present results suggest that BDNF may contribute 
      to the neuroprotective effects of rTMS. Furthermore, the rTMS-induced changes in 
      BDNF and CCK expression are similar to those reported after antidepressant drug 
      treatment and electroconvulsive seizures, suggesting that a common molecular 
      mechanism may underlie different antidepressant treatment strategies.
FAU - Muller, M B
AU  - Muller MB
AD  - Max Planck Institute of Psychiatry, Munich, Germany.
FAU - Toschi, N
AU  - Toschi N
FAU - Kresse, A E
AU  - Kresse AE
FAU - Post, A
AU  - Post A
FAU - Keck, M E
AU  - Keck ME
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuropeptide Y)
RN  - 0 (RNA, Messenger)
RN  - 9011-97-6 (Cholecystokinin)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/genetics
MH  - Cerebral Cortex/metabolism
MH  - Cholecystokinin/biosynthesis/*genetics
MH  - Dentate Gyrus/metabolism
MH  - Electric Stimulation/instrumentation
MH  - Hippocampus/metabolism
MH  - Male
MH  - Neuropeptide Y/biosynthesis/*genetics
MH  - Olfactory Pathways/metabolism
MH  - Parietal Lobe/metabolism
MH  - RNA, Messenger/*biosynthesis
MH  - Rats
MH  - Rats, Wistar
MH  - Time
MH  - Transcranial Magnetic Stimulation/*therapeutic use
EDAT- 2000/07/07 11:00
MHDA- 2000/09/09 11:01
CRDT- 2000/07/07 11:00
PHST- 2000/07/07 11:00 [pubmed]
PHST- 2000/09/09 11:01 [medline]
PHST- 2000/07/07 11:00 [entrez]
AID - S0893-133X(00)00099-3 [pii]
AID - 10.1016/S0893-133X(00)00099-3 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2000 Aug;23(2):205-15. doi: 
      10.1016/S0893-133X(00)00099-3.