PMID- 10884046
OWN - NLM
STAT- MEDLINE
DCOM- 20001222
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 11
IP  - 9
DP  - 2000 Jun 26
TI  - Astrocytic alteration induced by Japanese encephalitis virus infection.
PG  - 1933-7
AB  - The neurotropism of Japanese encephalitis virus (EV) has not been well 
      characterized. Astrocytes are parts of the blood-brain barrier, a major source of 
      chemokines, and critical effectors of central inflammation. Thus, astrocytes 
      might play some role as JEV travels from the peripheral to the CNS and/or the 
      resultant encephalitis. Using rat cortical cultures, we found that JEV can cause 
      cellular and/or functional changes in astrocytes as indicated by increased 
      expression of interleukin-6 (IL-6), regulated by activation, normal T cell 
      expressed and secreted (RANTES), and monocyte chemotactic protein 1 (MCP-1), 
      increased lactate release and glucose uptake, and attenuation of glutamate 
      toxicity. These modulations occur needed by the cells for compensation and may 
      affect neuron and/or astrocyte function.
FAU - Chen, C J
AU  - Chen CJ
AD  - Department of Education and Research, Taichung Veterans General Hospital, Taiwan, 
      ROC.
FAU - Liao, S L
AU  - Liao SL
FAU - Kuo, M D
AU  - Kuo MD
FAU - Wang, Y M
AU  - Wang YM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Cytokines)
RN  - 0 (Neurotoxins)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Animals
MH  - Astrocytes/drug effects/metabolism/*pathology
MH  - Coculture Techniques
MH  - Cytokines/metabolism
MH  - *Encephalitis Virus, Japanese
MH  - Encephalitis, Japanese/metabolism/*pathology
MH  - Glutamic Acid/poisoning
MH  - Neurons/pathology
MH  - Neurotoxins/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2000/07/07 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/07/07 11:00
PHST- 2000/07/07 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/07/07 11:00 [entrez]
AID - 10.1097/00001756-200006260-00025 [doi]
PST - ppublish
SO  - Neuroreport. 2000 Jun 26;11(9):1933-7. doi: 10.1097/00001756-200006260-00025.