PMID- 10885032
OWN - NLM
STAT- MEDLINE
DCOM- 20000811
LR  - 20131121
IS  - 0042-8809 (Print)
IS  - 0042-8809 (Linking)
VI  - 46
IP  - 2
DP  - 2000 Mar-Apr
TI  - [Processes of protein biosynthesis in cardiac muscle and cardioprotective effect 
      of mu-opiate receptor ligands in immobilization stress].
PG  - 127-34
AB  - Immobilization stress leads to the increase of 99mTc-pyrophosphate accumulation 
      in the heart that points to the cardiomyocyte damage. The stress-reaction was 
      accompanied by a decrease of protein synthesis rate in the heart muscle and 
      immunoreactive insulin level in blood plasma and increase of blood plasma 
      cortisol and aldosteron. Pretreatment with agonists mu-opioid receptors DALDA and 
      DAGO (0.1 mg/kg intraperitonealy (i.p.) twice during stress) completely prevented 
      the stress-induction decrease of myocardial protein synthesis rate, heart damage 
      and hormonal imbalance. Cycloheximide administration (0.3 mg/kg i.p.) increased 
      rats myocardial membrane injury during immobilization and reduced 
      cardioprotective effect of DALDA.
FAU - Naryzhnaia, N V
AU  - Naryzhnaia NV
AD  - Laboratory of Experimental Cardiology, Tomsk Institute of Cardiology. 
      nuclear@cardiolog.tomsk.su
FAU - Maslov, L N
AU  - Maslov LN
FAU - Lishmanov, Iu B
AU  - Lishmanov IuB
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Protsessy biosinteza belka v serdechnoi myshtse i kardioprotektornoe deistvie 
      ligandov mu-opiatnykh retseptorov pri immobilizatsionnom stresse.
PL  - Russia (Federation)
TA  - Vopr Med Khim
JT  - Voprosy meditsinskoi khimii
JID - 0416601
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Muscle Proteins)
RN  - 0 (Oligopeptides)
RN  - 0 (Receptors, Opioid, mu)
RN  - 100929-53-1 (Enkephalin, Ala(2)-MePhe(4)-Gly(5)-)
RN  - 118476-85-0 (tyrosyl-arginyl-phenylalanyl-lysinamide)
RN  - 98600C0908 (Cycloheximide)
SB  - IM
MH  - Animals
MH  - Cardiotonic Agents/metabolism/*pharmacology
MH  - Cycloheximide/pharmacology
MH  - Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/metabolism/pharmacology
MH  - Heart/drug effects
MH  - *Immobilization
MH  - Male
MH  - Muscle Proteins/*biosynthesis
MH  - Myocardium/*metabolism
MH  - Oligopeptides/metabolism/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Opioid, mu/*agonists/metabolism
MH  - Stress, Physiological/*metabolism
EDAT- 2000/07/08 11:00
MHDA- 2000/08/19 11:00
CRDT- 2000/07/08 11:00
PHST- 2000/07/08 11:00 [pubmed]
PHST- 2000/08/19 11:00 [medline]
PHST- 2000/07/08 11:00 [entrez]
PST - ppublish
SO  - Vopr Med Khim. 2000 Mar-Apr;46(2):127-34.