PMID- 10885316
OWN - NLM
STAT- MEDLINE
DCOM- 20001004
LR  - 20111117
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 58
IP  - 1
DP  - 2000 Jan
TI  - [HLA and hepatitis C virus positive cardiomyopathy].
PG  - 212-7
AB  - The relationship between HCV (hepatitis C virus) and the susceptibility of 
      cardiomyopathy has been indicated, but the detailed mechanism for close 
      association is still unknown. It is well known that the human leukocyte antigen 
      (HLA) may regulate the development of chronic hepatitis in HCV positive patients. 
      We have analyzed the distribution of HLA class II alleles in Japanese patients 
      with HCV antibody positive dilated cardiomyopathy (DCM) and hypertrophic 
      cardiomyopathy (HCM), and HLA-DPB1*0901 was significantly increased in HCV Ab 
      positive DCM, and the HLA-DRB1*0901-DQB1*0303 haplotype was in HCV Ab positive 
      HCM. These results suggested that molecular mechanism for the development of 
      cardiomyopathy mediated by HCV is different between DCM and HCM.
FAU - Naruse, T K
AU  - Naruse TK
AD  - Dept. of Genetic Imformation, Div. of Molecular Life Science, Tokai Univ. School 
      of Medicine.
FAU - Inoko, H
AU  - Inoko H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (Hepatitis C Antibodies)
SB  - IM
MH  - Alleles
MH  - Cardiomyopathies/*virology
MH  - Gene Frequency
MH  - HLA-DP Antigens/*genetics/metabolism
MH  - HLA-DP beta-Chains
MH  - *Hepacivirus/genetics
MH  - *Hepatitis C
MH  - Hepatitis C Antibodies/analysis
MH  - Humans
RF  - 15
EDAT- 2000/07/08 11:00
MHDA- 2000/10/07 11:01
CRDT- 2000/07/08 11:00
PHST- 2000/07/08 11:00 [pubmed]
PHST- 2000/10/07 11:01 [medline]
PHST- 2000/07/08 11:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 2000 Jan;58(1):212-7.