PMID- 10885794
OWN - NLM
STAT- MEDLINE
DCOM- 20000914
LR  - 20220310
IS  - 0301-4800 (Print)
IS  - 0301-4800 (Linking)
VI  - 46
IP  - 2
DP  - 2000 Apr
TI  - Resveratrol attenuates ovariectomy-induced hypertension and bone loss in 
      stroke-prone spontaneously hypertensive rats.
PG  - 78-83
AB  - We examined the effect of resveratrol (3,4',5-trihydroxy stilbene), a phenolic 
      compound found in the skins of most grapes, on blood pressure and bone loss in 
      ovariectomized (OVX), stroke-prone spontaneously hypertensive rats (SHRSP). 
      Nineteen-week-old female SHRSP were divided into a sham-ovariectomized (sham) 
      group fed a control diet and two OVX groups fed either a control diet (OVX-Cont) 
      or a diet supplemented with resveratrol (5 mg/kg per d; OVX-Resv). Ovariectomy 
      induced significant increases in systolic blood pressure (SBP). Resveratrol 
      lowered the SBP by 15%) by the third week of administration, and this effect was 
      maintained throughout the study. Resveratrol treatment also significantly 
      enhanced endothelium-dependent vascular relaxation in response to acetylcholine 
      (ACh) in OVX rats. Finally, femur breaking energies measured for the 
      resveratrol-treated (OVX-Resv) group were significantly higher than those of the 
      resveratrol-untreated (OVX-Cont) group. While no significant differences in 
      calcium, magnesium and phosphorus content were found between the femurs of 
      OVX-Cont and OVX-Resv rats, the femur hydroxyproline content in the OVX-Resv 
      group was significantly higher than of the OVX-Cont group. We conclude that, in 
      OVX-SHRSP, resveratrol acts by a similar mechanism to mammalian estrogens, 
      lowering blood pressure by increasing dilatory responses to ACh. The present 
      study also demonstrated that resveratrol was able to prevent ovariectomy-induced 
      decreases in femoral bone strength.
FAU - Mizutani, K
AU  - Mizutani K
AD  - Life Science, Environmental Conservation and Development, Graduate School of 
      Human and Environmental Studies, Kyoto University, Japan.
FAU - Ikeda, K
AU  - Ikeda K
FAU - Kawai, Y
AU  - Kawai Y
FAU - Yamori, Y
AU  - Yamori Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Nutr Sci Vitaminol (Tokyo)
JT  - Journal of nutritional science and vitaminology
JID - 0402640
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Stilbenes)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Antihypertensive Agents/pharmacology/therapeutic use
MH  - Bone Density/*drug effects
MH  - Disease Models, Animal
MH  - Female
MH  - Femur/drug effects/physiology
MH  - Hypertension/*drug therapy/etiology
MH  - Osteoporosis/etiology/*prevention & control
MH  - *Ovariectomy
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Resveratrol
MH  - Stilbenes/*pharmacology/therapeutic use
EDAT- 2000/07/08 11:00
MHDA- 2000/09/19 11:01
CRDT- 2000/07/08 11:00
PHST- 2000/07/08 11:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 2000/07/08 11:00 [entrez]
AID - 10.3177/jnsv.46.78 [doi]
PST - ppublish
SO  - J Nutr Sci Vitaminol (Tokyo). 2000 Apr;46(2):78-83. doi: 10.3177/jnsv.46.78.