PMID- 10885801
OWN - NLM
STAT- MEDLINE
DCOM- 20000725
LR  - 20151119
IS  - 1279-7707 (Print)
IS  - 1279-7707 (Linking)
VI  - 3
IP  - 2
DP  - 1999
TI  - Nutritional modulation of aging in nonhuman primates.
PG  - 69-76
AB  - Caloric restriction (CR), undernutrition without malnutrition, remains the only 
      experimental paradigm that has been shown consistently to extend lifespan and 
      slow aging in short-lived species. Decades of research, mostly in laboratory 
      rodents, have shown that CR consistently extends lifespan, reduces or delays the 
      onset of many age-related diseases and slows aging in many physiological systems. 
      In recent years gerontologists interested in CR have focused on two unanswered 
      questions. 1) What is the relevance of this nutritional paradigm to human aging? 
      and 2) What biological mechanism(s) underlie the diverse effects of CR leading to 
      a retardation of aging and disease?. To address the question of human relevance, 
      researchers in the Intramural Research Program of the National Institute on Aging 
      began a study of CR in nonhuman primates in the late 1980s. In addition to 
      assessing the effects of CR on aging in primates, a major focus of this work 
      relates to possible metabolic mechanisms of CR. A subsequent study at the 
      University of Wisconsin Madison was initiated in the early 1990s. Certain aspects 
      of experimental design differ between these two important ongoing investigations, 
      but generally these studies compliment each other in many ways and have begun to 
      provide much important data regarding the effects of CR in primates. Emerging 
      data from these studies strongly support that physiological responses to CR in 
      monkeys parallel the extensive findings reported in rodents. Lifespan data will 
      not be available for several years, however, the remarkable consistency with 
      rodent studies, in which lifespan extension is documented extensively, 
      strengthens the possibility that CR will also extend lifespan in primates, 
      perhaps including humans. This review summarizes the major findings from the 
      primate CR studies after over a decade of research in this model.
FAU - Lane, M A
AU  - Lane MA
AD  - Intramural Research Program, Gerontology Research Center, National Institute on 
      Aging, NIH, Baltimore, MD 21224, USA. MLANE@vms.grc.nia.nih.gov
FAU - Ingram, D K
AU  - Ingram DK
FAU - Roth, G S
AU  - Roth GS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aging/metabolism/*physiology
MH  - Animals
MH  - Biomarkers
MH  - Body Composition
MH  - *Energy Intake
MH  - Energy Metabolism
MH  - Female
MH  - Geriatrics
MH  - Humans
MH  - Longevity
MH  - Male
MH  - Primates/metabolism/*physiology
MH  - Research Design
RF  - 50
EDAT- 2000/07/08 00:00
MHDA- 2000/07/08 00:01
CRDT- 2000/07/08 00:00
PHST- 2000/07/08 00:00 [pubmed]
PHST- 2000/07/08 00:01 [medline]
PHST- 2000/07/08 00:00 [entrez]
PST - ppublish
SO  - J Nutr Health Aging. 1999;3(2):69-76.