PMID- 10885805
OWN - NLM
STAT- MEDLINE
DCOM- 20000725
LR  - 20071114
IS  - 1279-7707 (Print)
IS  - 1279-7707 (Linking)
VI  - 3
IP  - 2
DP  - 1999
TI  - Caloric restriction and genomic stability.
PG  - 102-10
AB  - Caloric restriction (CR) without malnutrition is the only experimental 
      manipulation that has consistently been shown to increase the mean and maximum 
      lifespan of laboratory rodents. It has been suggested that CR extends the 
      longevity of rodents and reduces the incidence of age-related pathological 
      lesions by reducing the levels of DNA damage and mutations that accumulate with 
      age within a cells genome. This hypothesis is attractive because the integrity of 
      the genome is essential to a cell/organism and because it is supported by the 
      observations that both cancer and immunological defects, which increase 
      significantly with age and are delayed by CR, are associated with changes in DNA 
      damage. However, all the evidence supporting the premise that the accumulation of 
      DNA damage/mutations plays a role in aging and CR is correlative, i.e., the 
      anti-aging action of CR-fed rodents is correlated with decreased DNA damage and 
      mutation and increased DNA repair capacity. Therefore, additional experiments are 
      required which employ more accurate assays of the DNA repair pathways as well as 
      genetically engineered animal models to establish the role of specific DNA repair 
      pathways and/or enzymes in the anti-aging action of CR. In this paper, we review 
      the proposed mechanisms of DNA damage/repair while providing insight into current 
      research that may assist in "unlocking" the mechanisms behind the life-prolonging 
      effect of CR.
FAU - Raffoul, J J
AU  - Raffoul JJ
AD  - Department of Nutrition & Food Science, Wayne State University, Detroit, Michigan 
      48202, USA.
FAU - Guo, Z
AU  - Guo Z
FAU - Soofi, A
AU  - Soofi A
FAU - Heydari, A R
AU  - Heydari AR
LA  - eng
GR  - AG14242/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
SB  - IM
MH  - Aging/*genetics/physiology
MH  - Animals
MH  - DNA Damage/*genetics
MH  - DNA Repair/*physiology
MH  - Energy Intake/*physiology
MH  - Female
MH  - Longevity
MH  - Male
MH  - Research
MH  - Rodentia
RF  - 123
EDAT- 2000/07/08 00:00
MHDA- 2000/07/08 00:01
CRDT- 2000/07/08 00:00
PHST- 2000/07/08 00:00 [pubmed]
PHST- 2000/07/08 00:01 [medline]
PHST- 2000/07/08 00:00 [entrez]
PST - ppublish
SO  - J Nutr Health Aging. 1999;3(2):102-10.