PMID- 10886754
OWN - NLM
STAT- MEDLINE
DCOM- 20000901
LR  - 20190910
IS  - 0736-8046 (Print)
IS  - 0736-8046 (Linking)
VI  - 17
IP  - 3
DP  - 2000 May-Jun
TI  - Disseminated BCG infection following bone marrow transplantation for X-linked 
      severe combined immunodeficiency.
PG  - 208-12
AB  - An 8-month-old boy with X-linked severe combined immunodeficiency (XSCID) 
      developed disseminated bacille Calmette-Guerin (BCG) infection following BCG 
      vaccination at birth. He initially presented with an abscess at the site of BCG 
      vaccination and was begun on three-drug antituberculous treatment (rifampicin, 
      isoniazid, and pyrazinimide). Dissemination was subclinical prior to a human 
      leukocyte antigen (HLA)-identical bone marrow transplant (BMT) from his sister, 
      following which he presented with an acute erythroderma. A skin biopsy specimen 
      revealed granulomas with epithelial histiocytes and giant cells in the reticular 
      dermis, and numerous acid-fast bacilli (AFB) were present on Ziehl-Nielsen stain. 
      A diagnosis of disseminated BCG disease was made. Despite the addition of a 
      fourth antituberculous agent, ethambutol, he did not recover and developed 
      numerous skin abscesses over the following weeks. Examination of pus from these 
      lesions demonstrated numerous AFB. Clarithromycin was added as a fifth 
      antituberculous agent. Despite five-drug antituberculous therapy and monthly 
      intravenous immunoglobulin infusions, recurrent abscesses containing AFB 
      developed intermittently until 7 months posttransplant. At follow-up 1 year 
      post-BMT he showed good general physical improvement. All abscesses had healed 
      with scarring, and no further skin lesions had occurred.
FAU - McKenzie, R H
AU  - McKenzie RH
AD  - Departments of Dermatology, Groote Schuur Hospital, Cape Town, South Africa.
FAU - Roux, P
AU  - Roux P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pediatr Dermatol
JT  - Pediatric dermatology
JID - 8406799
RN  - 0 (Antitubercular Agents)
RN  - 0 (BCG Vaccine)
SB  - IM
MH  - Abscess/etiology
MH  - Antitubercular Agents/therapeutic use
MH  - BCG Vaccine/*adverse effects
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Dermatitis, Exfoliative/etiology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Severe Combined Immunodeficiency/complications/*therapy
MH  - Tuberculosis/drug therapy/*etiology
MH  - Tuberculosis, Cutaneous/drug therapy/pathology
MH  - Vaccination/adverse effects
EDAT- 2000/07/08 11:00
MHDA- 2000/09/09 11:01
CRDT- 2000/07/08 11:00
PHST- 2000/07/08 11:00 [pubmed]
PHST- 2000/09/09 11:01 [medline]
PHST- 2000/07/08 11:00 [entrez]
AID - pde1754 [pii]
AID - 10.1046/j.1525-1470.2000.01754.x [doi]
PST - ppublish
SO  - Pediatr Dermatol. 2000 May-Jun;17(3):208-12. doi: 
      10.1046/j.1525-1470.2000.01754.x.