PMID- 10888335
OWN - NLM
STAT- MEDLINE
DCOM- 20001107
LR  - 20190819
IS  - 0960-894X (Print)
IS  - 0960-894X (Linking)
VI  - 10
IP  - 13
DP  - 2000 Jul 3
TI  - Design, synthesis, and biological evaluation of fluoronitrophenyl substituted 
      folate analogues as potential inhibitors of GAR transformylase and AICAR 
      transformylase.
PG  - 1471-5
AB  - The examination results of a novel series of potential inhibitors of glycinamide 
      ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide 
      transformylase (AICAR Tfase) are reported. These agents incorporate an 
      electrophilic fluoronitrophenyl group that can potentially react with an active 
      site nucleophile or the substrate GAR/AICAR amine via nucleophilic aromatic 
      substitution.
FAU - Boger, D L
AU  - Boger DL
AD  - Department of Chemistry and The Skaggs Institute for Chemical Biology, The 
      Scripps Research Institute, La Jolla, CA 92037, USA. boger@scripps.edu
FAU - Marsilje, T H
AU  - Marsilje TH
FAU - Castro, R A
AU  - Castro RA
FAU - Hedrick, M P
AU  - Hedrick MP
FAU - Jin, Q
AU  - Jin Q
FAU - Baker, S J
AU  - Baker SJ
FAU - Shim, J H
AU  - Shim JH
FAU - Benkovic, S J
AU  - Benkovic SJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioorg Med Chem Lett
JT  - Bioorganic & medicinal chemistry letters
JID - 9107377
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Nitro Compounds)
RN  - 0 (Purines)
RN  - 0 (Ribonucleotides)
RN  - 284SYP0193 (Fluorine)
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 2.1.2.- (Hydroxymethyl and Formyl Transferases)
RN  - EC 2.1.2.2 (Phosphoribosylglycinamide Formyltransferase)
SB  - IM
MH  - Animals
MH  - Biological Assay
MH  - Combinatorial Chemistry Techniques
MH  - Drug Design
MH  - Enzyme Inhibitors/*chemical synthesis/pharmacology
MH  - Fluorine/chemistry
MH  - Folic Acid/*analogs & derivatives/pharmacology
MH  - Hydroxymethyl and Formyl Transferases/*antagonists & inhibitors
MH  - Molecular Structure
MH  - Nitro Compounds/*chemical synthesis
MH  - Phosphoribosylglycinamide Formyltransferase
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma
MH  - Purines/biosynthesis
MH  - Ribonucleotides/*metabolism
MH  - Tumor Cells, Cultured
EDAT- 2000/07/11 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/07/11 11:00
PHST- 2000/07/11 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/07/11 11:00 [entrez]
AID - S0960-894X(00)00271-7 [pii]
AID - 10.1016/s0960-894x(00)00271-7 [doi]
PST - ppublish
SO  - Bioorg Med Chem Lett. 2000 Jul 3;10(13):1471-5. doi: 
      10.1016/s0960-894x(00)00271-7.