PMID- 10889480
OWN - NLM
STAT- MEDLINE
DCOM- 20000807
LR  - 20140728
IS  - 0194-5998 (Print)
IS  - 0194-5998 (Linking)
VI  - 123
IP  - 1 Pt 1
DP  - 2000 Jul
TI  - Quantification of rebound edema after steroid treatment.
PG  - 44-7
AB  - OBJECTIVE: Return of edema after abrupt discontinuation of steroid treatment has 
      never been studied or quantified. The purpose of this study was to measure the 
      effect of abrupt cessation and tapering doses of steroids on tissue water content 
      (TWC) in a rat skin flap model. DESIGN: A randomized controlled animal trial was 
      designed to study the effects of discontinuation of steroid on skin flap edema. 
      The animals were assigned to a control group (C), a steroid group (S), an abrupt 
      steroid cessation (SC) group, or a tapering steroid (ST) group. MAIN OUTCOME 
      MEASURES: In each group the skin flaps were biopsied at 30 and 36 hours. TWC was 
      determined by a biopsy-drying technique. RESULTS: A significant difference (P = 
      0.05) was found between the C and S groups and between the SC and S groups at 
      both 30 and 36 hours, with the C group having the highest TWC. No significant 
      difference was noted between the SC and C groups. The ST group had significantly 
      less edema than the C group and similar TWC to that of the S group. CONCLUSION: 
      Edema rebounded in the skin flaps after abrupt cessation of steroids (SC was not 
      different from C), presumably because of destabilization of inflammatory 
      mediators. The rebound effect was not observed in the ST group. The control of 
      rebound edema by a tapering steroid protocol may be important in skin flap 
      survival and may have implications for the management of airway edema.
FAU - Odland, R
AU  - Odland R
AD  - Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, Loma 
      Linda University, Loma Linda, CA, USA.
FAU - Wigley, T
AU  - Wigley T
FAU - Kim, T
AU  - Kim T
FAU - Kizziar, R
AU  - Kizziar R
FAU - Davamony, D
AU  - Davamony D
LA  - eng
PT  - Journal Article
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Edema/*chemically induced/pathology
MH  - Graft Survival/drug effects
MH  - Male
MH  - Methylprednisolone/administration & dosage/*toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Regional Blood Flow/drug effects
MH  - Substance Withdrawal Syndrome/*etiology/pathology
MH  - Surgical Flaps/*blood supply
MH  - Water-Electrolyte Balance/drug effects
EDAT- 2000/07/13 11:00
MHDA- 2000/08/12 11:00
CRDT- 2000/07/13 11:00
PHST- 2000/07/13 11:00 [pubmed]
PHST- 2000/08/12 11:00 [medline]
PHST- 2000/07/13 11:00 [entrez]
AID - S0194-5998(00)85687-9 [pii]
AID - 10.1067/mhn.2000.107404 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2000 Jul;123(1 Pt 1):44-7. doi: 
      10.1067/mhn.2000.107404.