PMID- 10889532
OWN - NLM
STAT- MEDLINE
DCOM- 20000912
LR  - 20191104
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 5
IP  - 3
DP  - 2000 May
TI  - Abnormal expression of brain-derived neurotrophic factor and its receptor in the 
      corticolimbic system of schizophrenic patients.
PG  - 293-300
AB  - Previous neuropathological studies have revealed that the corticolimbic system of 
      schizophrenic patients expresses abnormal levels of various synaptic molecules, 
      which are known to be influenced by the neuronal differentiation factors, 
      neurotrophins. Therefore, we determined levels of neurotrophins and their 
      receptors in the postmortem brains of schizophrenic patients and control subjects 
      in relation to molecular impairments in schizophrenia. Among the neurotrophins 
      examined, levels of brain-derived neurotrophic factor (BDNF) were elevated 
      specifically in the anterior cingulate cortex and hippocampus of schizophrenic 
      patients, but levels of nerve growth factors and neurotrophin-3 showed no change 
      in any of the regions examined. In parallel, the expressions of TrkB receptor and 
      calbindin-D, which are both influenced by BDNF, were reduced significantly in the 
      hippocampus or the prefrontal cortex. However, neuroleptic treatment did not 
      appear to mimic the neurotrophic change. Neither withdrawal of drug treatment in 
      patients nor chronic administration of haloperidol to rats altered levels of 
      BDNF. These findings suggest that neurotrophic abnormality is associated with the 
      corticolimbic structures of schizophrenic patients and might provide the 
      molecular substrate for pathological manifestations of the illness.
FAU - Takahashi, M
AU  - Takahashi M
AD  - Molecular Neurobiology, Brain Research Institute, Niigata University, 951-8585, 
      Japan.
FAU - Shirakawa, O
AU  - Shirakawa O
FAU - Toyooka, K
AU  - Toyooka K
FAU - Kitamura, N
AU  - Kitamura N
FAU - Hashimoto, T
AU  - Hashimoto T
FAU - Maeda, K
AU  - Maeda K
FAU - Koizumi, S
AU  - Koizumi S
FAU - Wakabayashi, K
AU  - Wakabayashi K
FAU - Takahashi, H
AU  - Takahashi H
FAU - Someya, T
AU  - Someya T
FAU - Nawa, H
AU  - Nawa H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - J6292F8L3D (Haloperidol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Autopsy
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cause of Death
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Gyrus Cinguli/metabolism/*pathology
MH  - Haloperidol/pharmacology
MH  - Hippocampus/metabolism/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prefrontal Cortex/metabolism/pathology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/*genetics
MH  - Reference Values
MH  - Schizophrenia/*genetics/pathology
EDAT- 2000/07/13 11:00
MHDA- 2000/09/19 11:01
CRDT- 2000/07/13 11:00
PHST- 2000/07/13 11:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 2000/07/13 11:00 [entrez]
AID - 10.1038/sj.mp.4000718 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2000 May;5(3):293-300. doi: 10.1038/sj.mp.4000718.