PMID- 10891884
OWN - NLM
STAT- MEDLINE
DCOM- 20000831
LR  - 20231120
IS  - 1059-910X (Print)
IS  - 1059-910X (Linking)
VI  - 50
IP  - 3
DP  - 2000 Aug 1
TI  - TNF alpha and the TNF receptor superfamily: structure-function relationship(s).
PG  - 184-95
AB  - Tumour Necrosis Factor alpha (TNF alpha), is an inflammatory cytokine produced by 
      macrophages/monocytes during acute inflammation and is responsible for a diverse 
      range of signalling events within cells, leading to necrosis or apoptosis. The 
      protein is also important for resistance to infection and cancers. TNF alpha 
      exerts many of its effects by binding, as a trimer, to either a 55 kDa cell 
      membrane receptor termed TNFR-1 or a 75 kDa cell membrane receptor termed TNFR-2. 
      Both these receptors belong to the so-called TNF receptor superfamily. The 
      superfamily includes FAS, CD40, CD27, and RANK. The defining trait of these 
      receptors is an extra cellular domain comprised of two to six repeats of cysteine 
      rich motifs. Additionally, a number of structurally related "decoy receptors" 
      exist that act to sequester TNF molecules, thereby rescuing cells from apoptosis. 
      The crystal structures of TNF alpha, TNF beta, the extracellular domain of TNFR-1 
      (denoted sTNFR-1), and the TNF beta sTNFR-1 complex have been defined by 
      crystallography. This article will review the structure/function relationships of 
      the TNF alpha and the TNF receptor superfamily. It will also discuss insights as 
      to how structural features play a role in the pleiotropic effects of TNF alpha.
CI  - Copyright 2000 Wiley-Liss, Inc.
FAU - Idriss, H T
AU  - Idriss HT
AD  - Centre for Biomolecular Sciences, The University, St. Andrews, Fife KY16 9ST, 
      Scotland, United Kingdom.
FAU - Naismith, J H
AU  - Naismith JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Microsc Res Tech
JT  - Microscopy research and technique
JID - 9203012
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Humans
MH  - Molecular Sequence Data
MH  - Receptors, Tumor Necrosis Factor/*chemistry/metabolism
MH  - Structure-Activity Relationship
MH  - Tumor Necrosis Factor-alpha/*chemistry/genetics/physiology
RF  - 116
EDAT- 2000/07/13 11:00
MHDA- 2000/09/02 11:01
CRDT- 2000/07/13 11:00
PHST- 2000/07/13 11:00 [pubmed]
PHST- 2000/09/02 11:01 [medline]
PHST- 2000/07/13 11:00 [entrez]
AID - 10.1002/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H [pii]
AID - 10.1002/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H [doi]
PST - ppublish
SO  - Microsc Res Tech. 2000 Aug 1;50(3):184-95. doi: 
      10.1002/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H.