PMID- 10893011
OWN - NLM
STAT- MEDLINE
DCOM- 20001107
LR  - 20191104
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 11
IP  - 2
DP  - 2000 May
TI  - Diagnosis of IgE-mediated food allergy among Swiss children with atopic 
      dermatitis.
PG  - 95-100
AB  - Diagnosis of food allergy in children with atopic dermatitis (AD) relies on a 
      good knowledge of the prevalence of the disease and of the foods most frequently 
      involved. Our objective was to define these characteristics in a population-of 
      Swiss children with AD. Patients referred to a pediatric allergist or a 
      dermatologist for AD were routinely tested by skin-prick test (SPT) to seven 
      common food allergens (milk, egg, peanut, wheat, soy, fish, and nuts), and to all 
      other foods suspected by history. Patients with positive SPTs were further 
      evaluated for specific serum immunoglobulin E (IgE) antibodies (by using the CAP 
      System FEIA ). CAP values were interpreted following previously published 
      predictive values for clinical reactivity. Patients with inconclusive results 
      (between the 95% negative predictive value [NPV] and the 95% positive predictive 
      value [PPV]) were challenged with the suspected food. A total of 74 children with 
      AD were screened for food allergies. Negative SPTs excluded the diagnosis in 30 
      subjects. Nineteen patients were diagnosed by histories suggestive of recent 
      anaphylactic reactions to foods and/or CAP values above the 95% PPV. Forty-three 
      food challenges (35 open challenges and eight double-blind, placebo-controlled in 
      children with persistent lesions of AD despite aggressive topical skin treatment) 
      were performed in patients with positive SPTs but with inconclusive CAP values. 
      Six patients were diagnosed as positive to 15 foods. Challenges were not 
      performed to high-allergenic foods in young children (under 12 months of age for 
      egg and fish, and under 3 years of age for peanuts and nuts). Altogether, 33.8% 
      (25 of 74) of the AD patients were diagnosed with food allergy. The prevalence of 
      food allergy was 27% (seven of 25) in the group referred to the dermatologist for 
      primary care of AD. The foods most frequently incriminated were egg, milk, and 
      peanuts. The prevalence of food allergy in our population was comparable to that 
      in other westernized countries, suggesting an incidence of food allergy in 
      approximately one-third of children with persistent lesions of AD. Together with 
      milk and eggs, peanuts were most frequently involved in allergic reactions.
FAU - Eigenmann, P A
AU  - Eigenmann PA
AD  - Department of Pediatrics, University of Geneva School of Medicine, Switzerland. 
      Philippe.Eigenman@hcuge.ch
FAU - Calza, A M
AU  - Calza AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Animals
MH  - Arachis/immunology
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/*complications
MH  - Female
MH  - Fishes/immunology
MH  - Food Hypersensitivity/complications/*diagnosis/epidemiology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Male
MH  - Milk Hypersensitivity/immunology
MH  - Prevalence
MH  - Skin Tests
MH  - Switzerland/epidemiology
MH  - Triticum/immunology
EDAT- 2000/07/13 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/07/13 11:00
PHST- 2000/07/13 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/07/13 11:00 [entrez]
AID - 10.1034/j.1399-3038.2000.00071.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2000 May;11(2):95-100. doi: 
      10.1034/j.1399-3038.2000.00071.x.